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 Expert  107951

Expert in Controlled Release, Microencapsulation, Drug delivery, Taste Masking, Bioavailability Enhancement


Available for your Consulting and Expert Witness Needs

Missouri (MO)
USA
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise: Listed with other top experts in: 
Expert has almost twenty years of experience in the formulation of pharmaceuticals for controlled release delivery. This work includes drug bioavailability enhancement, tastemasking, enteric protection, tableting, colonic delivery, prevention of ingredient interaction, nasal delivery, and buccal delivery. He has employed various coating and encapsulation methods including spray drying and developed new techniques for controlling release kinetics. He co-authored a recently published two book chapters on microencapsulation of food additives, a chapter on pediatric dosage forms and formerly published a chapter in a text on coating for the series Pharmaceutical Unit Operations. He has over ten patents mainly in the area of controlled release and has lectured widely in the U.S., Europe, and Australia.
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controlled-release drug delivery technology

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controlled-release oral drug delivery

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controlled-release drug delivery

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drug bioavailability

Expert has been involved in the formulation and process development for flavor and food additive microencapsulation using modified spray drying, spray chilling, pan coating, and fluid bed coating techniques. Applications have included improved particle size distributions, prevention of losses of more volatile components, improved bioavailability of nutritional supplements, prevention of ingredient interactions in storage, tastemasking of vitamin or mineral components, and stabilization of ingredients to process conditions. Expert has worked to build varying release kinetics into the formulations. He is familiar with most of the latest food ingredients, including the new, modified starches and uses for various gums and process aids. He has made dramatic improvements in the area of improved delivery and bioavailability of nutrition supplements, many of which are patentable.
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flavor microencapsulation

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food additive microencapsulation

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microencapsulation

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microencapsulation application

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organic compound microencapsulation

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inorganic compound microencapsulation

Expert has carried out a variety of liquid encapsulation techniques (both organic or inorganic), including spray drying, spray chilling (dispersions of liquids in melts), interfacial polymerization, and urea formaldehyde resin techniques. He is familiar with and has performed each of these techniques and knows their individual strengths and drawbacks as well as many of the operational tricks that are not always readily available in the literature. He has conducted solid encapsulations using fluid bed coating, spray chilling, spinning disk coating, as well as several other techniques. Expert has co-authored several book chapters with reviews of many of these techniques. He understands the right questions to ask and knows the parameters that must be understood in order to design the proper encapsulation technique or delivery system.
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liquid microencapsulation

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microorganism microencapsulation

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solid microencapsulation

Often more difficult than one might suspect, Expert has extensive experience with tastemasking. Factors such as size of dose, the nature of the taste sensation, the solubility of the particular active ingredient, the available form (powder, crystal), the need for a particular release profile, the delivered dosage form (suspension, sprinkles, fast release tablet, etc.) and the required amount of dose can all weigh into the decisions as to how to proceed with a development effort. He has experience in masking the taste of some of the most foul antibiotics, analgesics, and nutritional supplements, as well as some excipient materials.
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tastemasking

Expert has operational familiarity with Niro, Anhydro, Bowen, and Drytec spray dryers. He has developed formulations in the laboratory and carried the formulations through pilot trials and into production. He has successfully developed formulations in the area of foods, pharmaceuticals, cosmetics, nutritional supplements, agricultural chemicals, bacteria, and enzymes. Expert has modified atomizers, drying chambers, outlet configurations, etc. to successfully complete the drying development. He also developed formulations that allowed successful drying where other groups had failed to obtain a flowable or viable product. He has been invited to present this topic at industrial short courses on spray drying given in both the US and Europe.
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spray drying


Show Secondary and Basic Areas of Expertise
Localities:
Expert may consult nationally and internationally, and is also local to the following cities: Saint Louis, Missouri;  Columbia, Missouri;  Saint Charles, Missouri;  Saint Peters, Missouri;  Florissant, Missouri;  and Springfield, Illinois.

Often requested
with this expert:

Food Additives and Ingredients, Food Processing
All Aspects of Spray Drying
Natural & Processed Cheeses, Spray Drying, Food Processing...
Food Product Development: Pilot Plant Processes,...

Education:
Year   Degree   Subject   Institution  
1975   Post Doctoral Studies completed   Pharmacy   Ohio State University, Pharmacy College  
1974   PhD   Organic Chemistry (Molecular Biochemistry Minor)   The Johns Hopkins University  
1970   BS   Chemistry   Drexel University  

Work History:
Years   Employer   Department   Title   Responsibilities

2010 to 2013

 

Particle Dynamics, Int.

 

Research & Development

 

Vice President

 

oversaw all Research efforts within the company

2007 to 2009

 

KV Pharmaceutical

 

Research & Development

 

Director of Drug Delivery Technology

 

He directed development of several generic formulations as well as having a team for the development of new drug delivery technologies using nanoparticle techniques and emulsion technology. Other technologies were examined including gastro-retentive dosage forms and transdermal technologies. He also was responsible for technical assessment of outside technologies for possible licensing and looking at possible formulations to address unmet medical needs.

1994 to 2007

 

Particle and Coating Technologies, Inc.

 


 

Director, Chemical Technology

 

Directed day-to-day operations of the company including presentations to clients, proposals, experimental design, supervision of experimental studies and reporting.

1989 to 1994

 

Washington University, Chemical Engineering Department

 


 

Research Associate

 

He supervised research in a group doing contract research including students and full-time technicians as well as assisting in experimental design with gradualte students.

1981 to 1989

 

Petrolite Corporation

 


 

Senior Chemist/Specialist

 

Formulations research specialist

1979 to 1981

 

Ingersoll Rand

 


 

Training Supervisor

 


1975 to 1979

 

Rockhurst College

 


 

Assistant Professor

 


2014 to 2015

 

Expert Controlled Release Consulting

 


 

Managing Director

 

Consulting work on bioavailability enhancement, scale-up of manufacturing processes, extended release formulations, expert witness


Career Accomplishments:
Associations/Societies

Expert is a member of the American Chemical Society, the Controlled Release Society, the American Association of Pharmaceutical Scientists.

Awards/Recognition

Expert was nominated as Danforth Scholar in 1979 in recognition for teaching and scholarly research while at Rockhurst College.


Publications:
Publications and Patents Summary

Expert has eleven U.S. patents in the areas of controlled release, dosage form development, and bioavailability.

Selected Publications and Publishers  
 - Pharmaceutical Unit Operations-Coating. Interpharm Press, pp. 177-218. Buffalo Grove, Illinois  
 - Polymeric Delivery Systems. ACS Symposium Series 520. American Chemical Society, Washington, D.C.  
 - Marcel Dekker  

Consulting Services:
Selected Consulting Examples:
  • Expert has been able to suggest new formulations or process conditions that have been implemented. Modification of techniques outside the norm were successful where on-site personnel would have sworn it was not going to work.
  • Expert is often called on to advise whether a controlled release technique is in fact, necessary and if so provide some approaches to solving the particular problems.
Recent Client Requests:
  • Expert in spray drying toll work new york for consulting on Moringa leaf powder spray drying.
  • Expert soluble coffee for consulting on coffee.
  • Micro encapsulation expert for consulting on the refinement, concentration and micro encapsulation of Omega 3 bearing fish oil for use in functional food applications.
  • Expert in Spray drying microcapsules.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Expert has been called as a witness and has given depositions in four law suits involving patent infringement and obviousness.
Recent Litigation Client Requests:
  • Pharmaceutical manufacturing expert for trade secret litigation case.
  • Expert in controlled release drugs for consulting on Doryx tablets for patent litigation.
  • Expert in tablet formulation to prepare APAP tablet pursuant to formulation in lab notebook.
  • Expert for consulting on Trade Secret Litigation - Nutritional Supplement Industry.
  • Expert in spray drying in food flavoring applications for litigation case.
  • Food technology expert for consulting on determining the release of diacetyl in an encapsulated flavor.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Country / Region   Summary
United Kingdom, Germany, The Netherlands, France   United Kingdom: Expert conducted numerous plant trials, business presentations, and research laboratory consultations. He supervised short-term laboratory development efforts. Germany: He was involved with a major plant trial at a large site and a laboratory pilot trial. He also made technical presentations.

The Netherlands: Expert made numerous technical presentations and conducted laboratory consulting in the Netherlands.

France: While in France, Expert was active in two pilot trials, including work with the installation of equipment and on-site formulation development. He made several technical presentations.


Market Research:
In oil well stimulation chemicals, Expert worked in technical services and as a technical liaison, speaking to well service companies and oil company research laboratories.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:
Training/Seminars

Expert was a course director for the Center for Professional Advancement for many years and have given several onsite courses in the last several years..

Supplier and Vendor Location and Selection

Expert has experience locating vendors of the following: * Contract spray drying/spray chilling * Contract research in microencapsulation, contract particle milling, and contract encapsulation services.


 

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