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 Expert  720719

Expert in Mass Spectrometry, HPLC/MS, Ion Trap MS, LC/MS/MS in environmental, food, proteomic and pharmicutical analysis

Available for your Consulting and Expert Witness Needs

North Carolina (NC)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

Expert has been responsible for developing mass spectroscopic methods for use on environmentally and biologically significant compounds. While he has employed HPLC/MS and CE/MS on quadrupoles, sectors and ion trap mass spectrometers for positive and negative ion detection of specific compounds, Expert has extensive experience in analyzing environmentally and biologically significant compounds using other methods. These include direct probe MS, gas chromatography/high-resolution mass spectrometry (GC/HRMS), and MS/MS as well as CI and FAB mass spectrometric techniques. His research in mass spectrometry has resulted in over 230 publications and presentations.

mass spectroscope

GC/MS analysis has been used for the determination of volatile organic compounds desorbed from cartridges (e.g. tenax) semivolatile organics in the environment (e.g. PAH's, PCB, TCDD, and pesticides) and pharmaceuticals. Expert is experienced in EI, CI, and NCI techniques using low resolution, high resolution, and tandem mass analyzers.

gas chromatography/mass spectrometry

Expert has been active in the field of mass spectrometry since 1979. He has build, improved, optimized, repaired and/or purchased instruments including single quadrupoles, triple quadrupoles, high resolution magnetic sector instruments, and ion traps mass spectrometry.

mass spectrometer

Expert has worked on the development and evaluation of electrospray HPLC/MS for the analysis of high molecular weight opioid peptides at the femtomolar level, as well as the analysis of cyclodextrins to correlate chemical modification of the structure with binding to organophosphate poisons. He has also worked on the development of electrospray HPLC/MS methods to insure food safety, and has evaluated the use of electrospray HPLC/MS to determine compounds of environmental interest. These include dyes, pesticides, and herbicides. He currently has four electrospray HPLC/MS systems in the laborato. This experience ranges from impurity and metabolite identification to quantitative analysis of target drugs for pharmacokinetic studies.

electrospray ionization


mass spectrometry

Expert's pioneering work in HPLC/MS has demonstrated that this method can be used to perform analyses of compounds not amenable to analysis by GC/MS or MS/MS. He developed a research program around HPLC/MS and HPLC/MS/MS using electrospray, thermospray and particle beam interfaces. He investigated fundamental principles of the applications of these techniques to current analytical problems. He has used HPLC/MS for the analysis of EPA Appendix VIII compounds, dyes, pesticides, herbicides, numerous drugs and their metabolites of pharmaceutical interest (e.g., AIDS drugs, anticancer drugs, antimalarials), mycotoxins and their metabolites, natural products, peptides, nucleotides, and proteins. He has seven HPLC/MS interfaces: two thermospray, one particle beam and four electrospray. He has over 180 publications and presentations in the area of HPLC/MS.

liquid chromatography/mass spectroscopy


high-performance liquid chromatography/mass spectroscopy

Expert has combined CE with electrospray-MS using a layer flow interface. He is using CE/MS to identify DNA adducts formed by exposure to epoxides and nitro compounds. He has also developed quantitative CE/ MS methods for (beta)-lactams antibiotics in milk and peptides in blood.

capillary electrophoresis

Expert has used particle beam equipment to acquire EI and CI spectra from compounds of environmental and biomedical interest, such as dyes, pesticides, herbicides, nitro compounds, aromatic amines, antibiotics, and anticancer drugs. He has also investigated fundamental particle transport and transport efficiency in the particle beam interface for various sample and LC conditions.

particle beam liquid chromatography/mass spectroscopy

Expert has investigated and applied thermospray HPLC/MS since 1983 on two different instruments. He has investigated fundamental parameters that effect sensitivity and specificity. In addition he has applied thermospray HPLC/MS to solve various environmental and biological chemicals. These include pesticides, herbicides, dyes, antibiotics, nucleotides, peptides, anticancer drugs and other pharmaceuticals.

thermospray HPLC/mass spectroscopy

Expert has investigated ion trap mass spectrometry, looking at both fundamental gas phase ion chemistry and its applications for GC/MS, HPLC/MS and CE/MS analysis. Expert has linked an electrospray interface to the ion trap to determine environmental, pharmaceutical, and biological compounds. He is experienced in its MS/MS capabilities, in ways to inject ions from external sources, and in mass range extension.

ion trap mass spectrometry

For the past nine years, Expert has been working with FDA, developing new, more specific and more sensitive methods to detect trace residues in food products. His work primarily used LC/MS, GC/MS, and LC methods to detect antibiotics and common vetinary drugs in foods as well as pesticides and herbicides in food products.

food analytical chemistry

Expert has been using mass spectrometry for the past 25 years to perform trace analyses in biological and environmental media. He has worked with numerous pharmaceutical companies, FDA, EPA, and the National Institute of Drug Abuse in developing and validating methods as well as analyzing samples in the 1pg/mL to 1ng/mL range.

trace analysis



Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Raleigh, North Carolina;  Greensboro, North Carolina;  Durham, North Carolina;  Winston Salem, North Carolina;  Fayetteville, North Carolina;  Cary, North Carolina;  High Point, North Carolina;  Greenville, North Carolina;  Concord, North Carolina;  and Lynchburg, Virginia.

Year   Degree   Subject   Institution  
1982   Ph.D.   Analytical Chemistry   University of North Carolina  
1978   B.S.   Chemistry   Canisius College, Buffalo, N.Y.  

Work History:
Years   Employer   Department   Title   Responsibilities

2001 to







Expert oversees operation of Expert's Firm technical services in mass spectrometry, their training program, and development of new products and services.

1983 to 2001


Research Triangle Institute, Research Triangle Park, North Carolina


Analytical & Chemical Sciences


Senior Research Mass Spectrometrist


Career Accomplishments:

Expert is a member of the American Chemical Society and the American Society for Mass Spectrometry.

Professional Appointments

Expert is Adjunct Associate Professor at North Carolina State University, Department of Anatomy, Physiological Sciences and Radiology and an Adjunct Professor at the University of North Carolina at Chapel Hill School of Pharmacy. He reviews proposals submitted to the EPA, NSF, and the North Carolina Board of Science and Technology as well as articles submitted to several journals including Analytical Chemistry, Biological Mass Spectrometry, Journal of the American Society for Mass Spectrometry, and the Journal of Chromatography. He has chaired national conferences on Mass Spectrometry. From 1996-1998 he served as an American Society for Mass Spectrometry board member "member-at-large for measurement and standards." He has organized and hosted the 12th International Montreux LC/MS Symposium held at Hilton Head Island, SC, Oct. 30-Nov. 3, 1995, and organized the 16th Montreux symposium in 1999. He was a co-organizer for the 7th Sanibel Conference on Mass Spectrometry (Sanibel Island, FL, Jan. 21-24, 1995) on the Physics and Chemistry of Electrospray and Multiple Charged Ions. He also serves as an "A-page" advisor for Analytical Chemistry and is on the Editorial Advisory Board for the CRC Press Series "Modern Mass Spectrometry."


He received the RTI President's Award for securing new equipment for industry in the laboratory.

Publications and Patents Summary

Expert has written over 300 publications and presentations.

Selected Publications and Publishers  
 - Chromotography  
 - Electrospray Ionization Mass Spectrometry Fundamentals  
 - CRC Press  
 - Environmental Science & Technology  
 - Analytical Chemistry  

Consulting Services:
Selected Consulting Examples:
  • Expert has presented over 50 on-site training classes on LC/MS.
  • He has conducted on-site method development and instrument training to meet clients' objectives.
  • Expert has performed an on-site review of an analytical chemistry program.
  • He conducted an on-site review of LC/MS results and methods.
  • Provide expert review of data and generated data to support clients claims in court cases
Recent Client Requests:
  • LC/MS/MS expert needed for consulting on method development.
  • Expert for lc/ms/ms drug of abuse for consulting on Choice of instrumentation.
  • Mass spectrometer expert freelance for consulting on GC/MS.
  • Expert in LC/MS/MS for consulting on LC/MS/MS operation.
  • LC-MS dye analysis expert for consulting on the possible contamination of a blue groundwater sample.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Expert has served as an expert witness to support analytical findings or to generate analytical data to support a case. He has been involved in nine different cases, provided 6 depositions and was on the stand in 3 different court cases.
Recent Litigation Client Requests:
  • Analytical chemistry expert witness for consulting on historical instrument methodology and uses.
  • Expert witness liquid chromotography for consulting on chemical analysis of deer attractants.
  • Expert in textile testing for acrylic percent in rugs and blankets.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Country / Region   Summary
Europe   Expert conducted seminar tours and hands-on training on LC/MS.
Asia   He conducted seminar tours and hands on training on LC/MS.

Additional Skills and Services:

Expert has been a visiting lecturer on numerous occasions nationally. For the past ten years, he has been conducting international training and custom short courses in mass spectrometry. These courses include one-, two-, and four-day sessions on liquid chromatography/mass spectrometry (LC/MS), gas chromatography/mass spectrometry (GC/MS), and mass spectral interpretation. He has taught single-day courses on GC, LC, and capillary electrophoresis (CE). Expert can design courses to cover specific topics such as pharmaceutical and environmental areas. He can also cover newer topics like ion trap-MS, capillary electrophoresis/MS, electrospray-MS, and sample preparation. In addition, he has provided instrument-specific MS training for Hewlett Packard, with Bruker and PE Sciex training planned for 1998. Expert has delivered these courses for a number of clients including the American Society for Mass Spectrometry, over 10 pharmaceutical companies, ISSX, separation focused meetings (HPCE, HPLC), industry, and international government or industrial supported education and training programs.

Supplier and Vendor Location and Selection

Expert has experience locating vendors in the area of mass spectrometry, including GC/MS, LC/MS, electrospray mass spectrometry, thermospray LC/MS, and particle beam LC/MS.

He has access to printed materials and personal contacts for assistance in vendor location. The eight mass spectrometers in his lab represent most manufacturers and his experience with these instruments can prove valuable to a potential buyer.


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