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 Expert  715400

Expert in Anesthesiology, Physiology

Available for your Consulting and Expert Witness Needs

Minnesota (MN)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

Expert is an Associate Professor and Director of Research in the Department of Anesthesiology at the Expert's University. He has a joint appointment in physiology and is a core facultly member in the biomedical engineering institute. Prior to this, Expert worked for seven years as an Associate Professor in the Department of Anesthesiology at the Mayo Clinic. Thus, a large portion of his research has direct relevance to the fields of anesthesiology and physiology. Expert is a referee for the journals Anesthesiology, Anesthesia & Analgesia, and Acta Anesthesiologica Scandinavica. He has been a member of the American Society of Anesthesiologists since 1989.



inhalation general anesthesia

Expert has been active in the area of biological heat transfer for over 15 years. He has worked with warming and cooling therapies related to hyperthermia, hypothermia, exercise-induced heat stress, and more recently, wound healing. These investigations have been directed at understanding the physiological basis of such therapies as well as biomedical product development. Expert is currently the director of the Expert's University's Biomedical Engineering course "Biomedical Aspects of Heat Transfer in Humans," in which he provides 10 hours of lectures.

biological heat transfer


biomedical engineering

A large portion of Expert's work deals with the clinical syndrome called malignant hyperthermia. This includes directing the Malignant Hyperthermia Diagnostic Center at the Expert's University and serving on the Board of Directors of the North American Malignant Hyperthermia Registry and the Professional Advisory Board of the Malignant Hyperthermia Association of the United States. Expert's research on this syndrome has ranged from improving diagnoses to determining if new anesthetic agents will trigger this syndrome under clinical conditions. Additional clinical conditions or disorders that Expert has performed research include: 1) treatment of essential and Parinsonian tremors, 2) treatment of clinical hyperthermia, 3) treatment of perioperative hypothermia, 4) treatment of myotonia, 5) application of lumbar traction, 6) force assessment in patients with various neuromuscular disorders, 7) wound assessment using computerized imaging, and 8) the prevention of pressure ulcers.

clinical medicine

Expert has been investigating decubitus ulcers and chronic wounds intensively for the past three years. He has used an animal model, the swine, to investigate the thresholds for tissue (cutaneous and subcutaneous) injury at various pressures, temperatures, and duration of application. Using this model, he has gained new insight as to the differences in ischemic thresholds between epidermal, dermal, subcutaneous fat, and underlying muscle layers (with the muscle being the most susceptible layer). In a study, he has shown that focal cooling (to 25C) of cutaneous areas under the application of high-pressure (100 mmHg) could prevent the formation of pressure ulcers. Based on these results, he is currently designing biomedical devices to implement this advantage. The work has been funded in part by the National Science Foundation and by industrial support.

chronic wound


decubitus ulcer

In several recent studies, Expert has used color and infrared imaging to investigate erythemic responses to applied pressure and temperature stimuli.


Expert has performed several investigations on the effects of exercise, some of which are ongoing. A number of physiologic parameters (heart rate, blood pressure, core temperature) were monitored throughout these studies as a means to determine the degree of stress induced by the exercise.

exercise physiology

Expert has performed numerous studies investigating the mechanism of action of general anesthetics on muscle and nerve function, as well as their effects on the regulation of intracellular calcium in general. Several of these investigations were to determine the relative potency of such agents to induce episodes of malignant hyperthermia in susceptible swine. He has published several papers in this area.

general anesthetic


local anesthetic

Expert has performed numerous investigations into the pathophysiology of human skeletal muscle. As Director of the Malignant Hyperthermia Diagnostic Center, he routinely performs in vitro contracture testing of live muscle samples from patients considered at risk for this syndrome.

human tissue

With a thorough knowledge of the consequences of hyperthermia and related modes of treatment, Expert lectures on these topics in the Expert's University's Biomedical Engineering course "Biomedical Aspects of Heat Transfer in Humans." He has experience working with a biomedical device company in developing convective-air cooling therapies to treat hyperthermia.


Expert has studied the regulation of intracellular calcium for over ten years. His doctoral thesis was on calcium transients detected with the photoprotein aequorin in single form skeletal muscle fibers. He has continued to use this indicator and other methodologies (fluorescent indicators and 45 Ca(2+) to monitor changes in intracellular calcium in a large variety of cell types (neuroblastoma, smooth muscle, fibroblasts, human and swine skeletal muscles, and hepatocytes). Expert has been publishing his work in this area since 1988.

intracellular calcium

For more than 15 years, Expert has been involved in physiological investigations of patients with various neuromuscular disorders, including myotonia, malignant hyperthermia, periodic paralyses, Parkinsonia tremor, essential tremor, clonus in paraplegics, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, and muscular dystrophy.

neuromuscular disorder


myasthenia gravis

The majority of Expert's research has focused on motor systems (skeletal muscle and its control). In addition, he has provided 15 hours of lectures in Expert's University's Health Sciences course "Physiology 3053/3056/5441, covering all aspects of human neurophysiology.





nervous system


central nervous system

Expert understands how changes in temperature will modulate cellular functions differently, depending on the type of process under investigation. A majority of his research has been thermally-related, ranging from the induction of mild hyperthermia to facility cerebral protection to the eventual fatal effects of hyperthermia initiated in humans or swine susceptible to malignant hyperthermia.

organism temperature effect

Expert has performed multiple studies to investigate muscle physiology. Such studies have been conducted on humans (in vivo and in vitro) as well as in situ and in vitro of various animal models. Mechanographic, electromyographic, electrophysiologic (microelectrode and voltage clamp), and intracellular calcium monitoring techniques have been used. He has also given numerous lectures on both research results as well as on the basic physiology of skeletal muscle.

skeletal muscle physiology

A thorough knowledge of skin physiology is needed to perform the various ongoing studies in Expert's laboratory on wound formation, prevention, and healing. In addition, in the Expert's University's Biomedical Engineering course "Biomedical Aspects of Heat Transfer in Humans," Expert gives a two-hour lecture on skin physiology.

skin physiology

Expert has collaborated on numerous clinically relevant studies in which either the effectiveness or a currently used therapeutic or a new approach to therapy were evaluated. These studies have included: 1) treating episodes of malignant hyperthermia using the calcium modulator dantrolene, 2) minimizing essential tremor by the application of topical anesthesia, 3) determining the efficacy of lumbar traction induced using a new biomedical device, and 4) performing quantitative force measurements in patients with various neuromuscular disorders to determine the result of therapy (e.g., IgG treatment of patients with chronic inflammatory demyelinating polyneuropathy).


Thermoregulation is an area of which Expert first began investigations as an undergraduate student in 1978. His initial work in this area concerned the physiological mechanisms that control shiver, but also included thermal and cardiovascular responses to exposure to cold air environments or water immersion. More recently, his work in this area has focused on the clinical treatment of perioperative hypothermia and the induction of mild hypothermia to facilitate cerebral protection. These studies not only have employed numerous methodologies to record physiological parameters of interest, but Expert has been involved with equipment design and testing to accomplish these desired effects.


Expert has been performing electrophysiological investigations as to the electrical properties of skeletal muscle sarcolemma for more than ten years. These investigations have been performed on both human muscle and various animal models for myopathies (e.g., myotonic mice, swine susceptible to malignant hyperthermia, and more recently, transgenic mice expressing human Na+ channel mutations). The properties of voltage-gated channels have been investigated by numerous methods, for example 1) recording extracellular EMG activity, 2) resting membrane potentials, 3) miniature endplate potentials, 4) action potentials, 5) current voltage relationships using a 3-electrode technique, and 6) using various patch clamp modes.

voltage-gated channel

Wound care has been an area of intensive investigation by Expert's laboratory for the past three years. He has used an animal model (the swine) to investigate the thresholds for tissue (cutaneous and subcutaneous) injury at various pressures, temperatures, and durations of application. He has evaluated the degree of wound formation and subsequent healing using numerous non-invasive methodologies that have been contrasted to histological analyses. The work has been funded in part by the National Science Foundation and by industrial support.



wound care


wound healing


Guillain-Barre syndrome



Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Minneapolis, Minnesota;  Saint Paul, Minnesota;  Rochester, Minnesota;  Burnsville, Minnesota;  Saint Cloud, Minnesota;  Eden Prairie, Minnesota;  Minnetonka, Minnesota;  and Eau Claire, Wisconsin.

Year   Degree   Subject   Institution  
1986   Ph.D.   Physiology (Neurophysiology)   (Undisclosed University)  
1980   M.S.   Physiology   (Undisclosed University)  
1978   BS   Biology   Expert's University--Duluth  

Work History:
Years   Employer   Department   Title  

1996 to


(Undisclosed University)


Anesthesiology and Physiology


Associate Professor


1995 to


(Undisclosed University)


Biomedical Engineering Institute


Core Faculty


1992 to


(Undisclosed University)


Center for Interfacial Engineering




1990 to


(Undisclosed University)




Director of Malignant Hyperthermia Muscle Biopsy Center


1990 to


(Undisclosed University)




Director of Anesthesia Research


1992 to 1996


(Undisclosed University)




Assistant Professor


1991 to 1996


(Undisclosed University)




Assistant Professor


1990 to 1991


(Undisclosed University)




Research Associate


Career Accomplishments:

Expert is a member of the American Society of Anesthesiologists, the Biophysical Society, the European Malignant Hyperpyrexia Group, the Minnesota Society of Anesthesiologists, and the North American Malignant Hyperthermia Registry.


Expert won the 1995 John Tate Award for Excellence in Academic Advising from the Expert's University. He received a Sea Grant Pre-Doctoral Traineeship (1979-81) and a National Institutes of Health Research Fellowship in 1986. He also received the Alexander von Humbolt-Stiftung Research Fellowship (1987-88) and its Collaborative Research Awards (seven travel awards for trips to Germany, 1988-92).

Selected Publications and Publishers  
 - Pflugers Archive, European Journal of Physiology  
 - Neuromuscular Disorders  
 - Wounds: A Compendium of Clinical Research and Practice  
 - Anesthesia and Analgesia  
 - International Conference on Environmental Ergonomics  

Consulting Services:
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Recent Litigation Client Requests:
  • Neuromuscular expert for consulting products liability case.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Country / Region   Summary
Germany   Expert did post-doctoral work in Germany and has visited the country every year since 1988. He is currently a Visiting Professor in Applied Physiology at the University of Ulm.

Language Skills:
Foreign Language   Description
German   Expert is proficient in German.

Additional Skills and Services:
Supplier and Vendor Location and Selection

Expert has experience locating vendors of physiological monitoring equipmen (for heart rate, blood pressure, muscle force, EMGs, and EEGs).


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