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 Expert  107690

Expert in Lipases, Biointerfaces, Instrumentation, Interaction of Drugs and Proteins with Lipids, Monolayers

Available for your Consulting and Expert Witness Needs

Minnesota (MN)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

LIPASES. Expert has spent most of his scientific career studying the regulation of lipases and other enzymes which function at oil-water interfaces. The emphasis of his work has been placed upon studying the role of lipid-lipid and lipid-protein interactions in the control of lipolysis at the molecular level. Lipids with which he has been particularly interested are lecithin, diacylglycerol, fatty acid, and cholesterol.

CHOLESTEROL ESTERASES. As a part of his study of lipases in general, Expert has devoted considerable effort to the study of cholesterol esterases. He notes that these are important enzymes in mammalian cholesterol homeostasis. The mammalian form most studied by Expert is that which belongs to the cholinesterase gene family. This is also known as bile-salt-stimulated lipase, lysophospholipase, carboxylester lipase, sterol ester hydrolase, and non-specific lipase.

ADSORPTION. Expert has extensive expertise in studying enzyme, peptide and drug adsorption to lipid-water interfaces. He notes that this has been necessitated by his lipase interest because lipases must adsorb to the lipid-water interface before they can act on substrates in it. The emphasis of his work on adsorption has been the retention of catalytic activity. Examples of this include the lack of protein denaturation and the role of the 2-dimensional organization of lipids in regulating protein adsorption. His recent focus has been on the application of percolation theory to the regulation of lipase adsorption and catalysis.

MONOMOLECULAR FILMS. Expert has made extensive use of monolayer techniques as a model lipid-water interface for studying lipase adsorption and catalysis. For analyzing such data, he has developed mathematical algorithms to characterize the surface potential-surface pressure-area characteristics of mixtures of lipids in monomolecular films. Lipids of interest to him have been phospholipids, acylglycerols, fatty acids, and cholesterol esters. Expert has developed automated instrumentation to facilitate the study of lipid-lipid and lipid-protein interactions in monomolecular films. He has emphasized the detection and elimination of surface-active impurities in this work. His goal in doing so has been to insure the accuracy and precision of his data.




cholesterol esterase




monomolecular film

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Minneapolis, Minnesota;  Saint Paul, Minnesota;  Rochester, Minnesota;  Burnsville, Minnesota;  Eden Prairie, Minnesota;  Minnetonka, Minnesota;  Waterloo, Iowa;  and La Crosse, Wisconsin.

Year   Degree   Subject   Institution  
1971   PhD   Biochemistry,   Michigan State University  
1966   BA   Chemistry,   DePauw University  

Work History:
Years   Employer   Department   Title   Responsibilities

1981 to


(Undisclosed University)


The Hormel Institute




Responsible for creating, funding executing research projects on lipid-lipid interactions as regulators of the interactions of enzymes, peptides and drugs with membranes

1977 to 1981


Expert's University, The Hormel Institute


The Hormel Institute


Associate Professor


1973 to 1977


Expert's University, The Hormel Institute


The Hormel Institute


Assistant Professor


1999 to







Developing an marketing software, consulting and instrumentation in the area of biophysical surface chemistry

Career Accomplishments:

Expert is a member of the American Chemical Society, the American Society of Biological Chemists, the Council on Atherosclerosis of the American Heart Association, the American Association for the Advancement of Science, and the Biophysical Society. In addition to his primary appointment, Expert is an Associate Faculty member of the self assembly processes group of the University of Minnesota's Center for Interfacial Engineering.

Professional Appointments

He is on the Editorial Board of the Journal of Lipid Research. In addition, he has been an Established Investigator of the American Heart Association from 1978-83.

Publications and Patents Summary

He has published over 60 technical papers.

Selected Publications and Publishers  
 - Acta Ophthalmologica Scandinavica  
 - Current Opinion in Structural Biology  
 - Chemistry and Physics of Lipids  
 - Journal of Biological Chemistry  
 - Langmuir  

Consulting Services:
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Language Skills:
Foreign Language   Description
French and German   Expert reads French and German.


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