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 Expert  713838

Expert in Dermal Drug Delivery

Available for your Consulting and Expert Witness Needs

Michigan (MI)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise: Listed with other top experts in: 
DERMAL ABSORPTION; SKIN ABSORPTION; MEMBRANE PERMEATION (ESPECIALLY SKIN). Expert has focused his laboratory work for over 20 years on the above topics, during which time he has written over 100 publications. His studies have included the influences of chemical structure on skin absorption, the prediction of skin permeability coefficients, the barrier properties of damaged skin, concepts and the strategies in transdermal delivery, functioning of topical dosage forms, bioavailability and bioequivalence of dermatological preparations.

BIOEQUIVALENCE. Expert is perhaps the leading expert in the influences of topical (dermatological) vehicles on the uptake of drugs into the skin, as well as absorption kinetics of drugs from thin-film applications. He has worked directly with FDA staff to establish regulatory guidelines for topical bioequivalence.

MASS TRANSPORT; MASS TRANSFER PROCESS. A major portion of Expert's research is concerned with the diffusion of drugs through membranes. He has general expertise in the influences of chemical structure on mass transport through membranes as a function of the physiochemical nature of the permeants and the membranes. He also is well-versed in the permeation of biological membranes.

CONTROLLED RELEASE DRUG DELIVERY; TRANSDERMAL DRUG DELIVERY. Expert has conducted substantial research on the dissolution, solubilities, and diffusion of organic chemicals: all the fundamental points and phenomena that actually "control" controlled release. He is actively engaged in the development of transdermal delivery systems for analgesics and other drugs, and participates in ongoing projects with respect to prodrugs for transdermal delivery. He also spent one year as Vice President of Research for Cygnus Therapeutic Systems, a transdermal delivery company, and has basic knowledge and skills in all phases of transdermal system development and testing.

SOLUBILITY PARAMETERS; SOLUBILITY THEORY. Expert has had an abiding interest in solubility throughout his career. He has conducted in-depth research on the solubility parameters and cohesive energies of the liquid state prediction of solubility parameters, as well as the cohesive energies of super-cooled liquids from solubility data.

DIFFUSION COEFFICIENT; PERMABILITY COEFFICIENT; PARTITION COEFFICIENT. Expert is an expert on the measurement of diffusion parameters and experimental methods, and has designed the commercial cells for such measurements.

PHASE EQUILIBRIUM. Expert's expertise includes the prediction of partition coefficients of organic compounds from chemical structure. He is also adept in the solubility of organic compounds in water and other solvents.

RISK ASSESSMENT. Expert has been responsible for the uptake of organic chemicals through skin from air, water, and soil.


dermal absorption


diffusion coefficient


phase equilibrium


skin absorption


skin permeation


solubility parameter


solubility theory


transdermal drug delivery

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Detroit, Michigan;  Warren, Michigan;  Flint, Michigan;  Sterling Heights, Michigan;  Lansing, Michigan;  Ann Arbor, Michigan;  Livonia, Michigan;  Dearborn, Michigan;  Westland, Michigan;  and Toledo, Ohio.

Often requested
with this expert:

Drug Delivery Using MEMS, Ultrasound, Electroporation and...
Biomaterials and Product Development R&D for Orthopedic,...
Composite Materials
FDA Regulatory Consultant for Medical Devices, Cosmetics,...

Year   Degree   Subject   Institution  
1965   PhD   Pharmaceutics   University of Wisconsin - Madison  
1960   BS   Pharmacy   Rutgers - The State University (New Jersey)  

Work History:
Years   Employer   Title  

1977 to


(Undisclosed University)


Professor Of Pharmaceutics


1978 to 1989


(Undisclosed University)


Associate Scientist, Dental Research Institute


1972 to 1977


(Undisclosed University)


Associate Professor of Pharmaceutics


1993 to


(Undisclosed University)


Sabbatical Professor


1988 to 1989


The University of California, San Francisco (UCSF)


Adjunt Professor of Pharmaceutical Chemistry


1988 to 1989


Cygnus Research Corporation


Vice President, Basic Research


1971 to 1972


Upjohn Co


Senior Research Scientist, Pharmacy Research


1965 to 1970


Upjohn Co


Research Associate


Career Accomplishments:

Expert holds memberships in numerous associations including: American Association of Pharmaceutical Scientists (AAPS), American Chemical Society (ACS), American Association for the Advancement of Science (AAAS), Society of Investigative Dermatology (SID), Sigma Xi, Rho Chi, and Pharmacology Study Section, NIH.

Professional Appointments

He is a Fellow of the Academy of Pharmaceutical Sciences and a Charter Fellow of the American Association of Pharmaceutical Sciences.


Expert received the Ebert Prize of the Academy of Pharmaceutical Sciences in 1973.

Publications and Patents Summary

He has published over 125 original research articles and other publications on pharmaceutical subjects.

Consulting Services:
Recent Client Requests:
  • Expert on FDA regulations relating to non-drug topical and transferal patches.
  • Expert in a dermatology drug delivery for Rx derm products.
  • Expert in formulation chemistry for consulting on dermal patch for cosmetics.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Recent Litigation Client Requests:
  • Expert pain management for consulting on fentanyl.
  • Cosmetic expert Firms for consulting on patent infringement matter.
  • Expert in pharmaceutical manufacturing.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:
Other Skills and Services

Expert has been very active as a planner and participant in programming concerning the problems of topical bioavailability and bioequivalency assessment.


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