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 Expert  716104

Expert in Carbohydrate Chemistry, Neoglycoconjugates, Conjugate Vaccines, Oligosaccharides, Glycoconjugates

Available for your Consulting and Expert Witness Needs

Maryland (MD)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

Expert is an internationally recognized authority in carbohydrate chemistry. With over 30 years of hands-on experience in this field, he is considered among the top experts in synthetic carbohydrate chemistry in the world. Among Expert's most important achievements is his work involving regulated syntheses of many biologically important complex carbohydrates, such as oligosaccharides and fluorosugars. Having designed and executed a variety of carbohydrate syntheses, Expert has published over two hundred scientific papers in these fields. Despite many managerial and supervisory duties, he manages to spend part of his day doing what he likes most: working in his chemical laboratory. During his long and successful career, Expert has acquired considerable experience in the crystallization of sugars and carbohydrate derivatives on a very small scale. He is also an expert in many instrumental techniques related to, and indispensable in synthetic carbohydrate chemistry. He is well recognized by his peers, which is best documented by the many invitations he has received to give seminars at scientific symposia or academic institutions.



carbohydrate analysis


carbohydrate chemistry





Expert has worked extensively with a variety of saccharides (sugars, carbohydrates). He can answer in-depth questions on the chemistry and structure determination of, monosaccharides, oligosaccharides and polysaccharides. He also has experience with crystallization of sugars and their derivatives at the microscale level.



saccharide crystallization




amino sugar




sugar chemistry

Expert is an internationally recognized expert on the chemical synthesis of oligosaccharides. During his career, which spans some thirty years, Expert has designed and executed syntheses of a large number of oligosaccharides. These are described in over one hundred papers published in international journals. Many of the oligosaccharides he has synthesized are fragments of 0-polysaccharides of bacterial pathogens. He and his colleagues synthesize oligosaccharides to be used to study interactions of carbohydrate antigens and biologically active proteins, such as immunoglobulins. He is a master of blocking strategies in carbohydrates, which helps him in manipulating their hydroxyl groups and, eventually, turn out complicated derivatives he and his colleagues use to satisfy their scientific curiosity. The recognition Expert has received by his peers is best represented by the invitation to organize a recent international symposium on synthetic oligosaccharides held during an ACS meeting. He edited a book on synthetic oligosaccharides, published by the American Chemical Society as Volume 560 of its Symposium Series.



oligosaccharide chemistry


oligosaccharide structure


oligosaccharide synthesis


antigen synthesis


vaccine development

Expert is also an expert in separation and instrumental techniques related to synthetic carbohydrate chemistry, such as thin-layer and preparative liquid chromatography, and nuclear magnetic resonance spectroscopy. He is familiar with sophisticated one and two-dimensional NMR techniques and is able to choose the technique most suitable to solving a structural problem that may arise.

liquid chromatography/mass spectroscopy


nuclear magnetic resonance spectroscopy


carbohydrate low-pressure preparative liquid chromatography

As an internationally recognized authority on synthetic carbohydrate chemistry, Expert has extensive experience in designing and executing multi-step syntheses of complex carbohydrate derivatives. The success of this work depends greatly on the ability of the chemist to manipulate hydroxyl groups in carbohydrates in such a way that the compatibility of blocking groups with various chemistries involved in a multi-step process not be compromised. Complex molecules resulting from each chemical manipulation have to be isolated in pure state and their structure has to be verified. Consequently, Expert has gained expertise in the associated separation and instrumental techniques.

carbohydrate synthesis


carbohydrate synthesis blocking strategy


complex carbohydrate synthesis

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Baltimore, Maryland;  Frederick, Maryland;  Gaithersburg, Maryland;  Bowie, Maryland;  Richmond, Virginia;  Alexandria, Virginia;  Wilmington, Delaware;  and Lancaster, Pennsylvania.

Year   Degree   Subject   Institution  
1968   Post-Doctoral Work   Organic Chemistry, Carbohydrate Chemistry, Polysaccharide Chemistry   Purdue University, Department of Biochemistry  
1967   PhD   Organic Chemistry, Wood Chemistry   Slovak Academy of Sciences, Inst. of Chem.  
1962   MS   Wood Chemistry   Slovak Technical University - Czechoslovakia  

Work History:
Years   Employer   Department   Title   Responsibilities

1983 to




NIDDK, LMC, Section on Carbohydrates


Research Chemist, Principal Investigator


Expert's primary responsibilities are to design, supervise and execute research in carbohydrate chemistry targeted towards development of conjugate vaccines from synthetic fragments (antigenic oligosaccharides) of bacterial LPS.

1981 to 1982


Bachem, Inc.



Group Leader


At Bachem, Expert executed on and supervised the production of oligonucleotides for machine synthesis of DNA fragments.

1969 to 1981


Institute of Chemistry, Slovak Academy of Sciences



Senior Researcher


He designed, executed and supervised research in synthetic carbohydrate chemistry.

Career Accomplishments:

Expert is a member of Editorial Boards for Carbohydrate Research and the Journal of Carbohydrate Chemistry.


In 1997, Expert received the Director's Award for advances in synthetic organic chemistry that have made a significant impact on the development of polysaccharide-based vaccines against cholera and shigella infections. He was also listed in the 1981-83 editions of Who's Who in the World and the 1985 Edition of Who's Who in Frontiers of Science and Technology.

Publications and Patents Summary

Expert has several patents and over 200 scientific papers in international scientific journals. He edited Vol. 560 of ACS Symposium Series: "Synthetic Oligosaccharides," and has written several chapters in monographs dealing with carbohydrate chemistry.

Selected Publications and Publishers  
 - Bioorganic & Medicinal Chemistry Letters  
 - Tetrahedron  
 - Carbohydrate Research  
 - Journal of the American Chemical Society (JACS)  
 - Harwood Academic Publishers  

Government Experience:
Years   Agency   Role   Description
1983 to   HHS, National Institute of Health   Scientist   Expert conducts research towards development of conjugate vaccines from synthetic fragments of bacterial polysaccharides.

Consulting Services:
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Recent Litigation Client Requests:
  • Expert in carbohydrate chemistry for consulting on ice ban.
  • Expert for consulting on false advertising dispute involving refinded sugar products.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Language Skills:
Foreign Language   Description
Slovak, Hungarian   A native of Czechoslovakia, Expert's first language is Slovak. He is also conversant in Hungarian.
English   He speaks fluent English.
German, Russian   Years back, Expert used to be quite fluent in both languages. Now his communication skills in German and Russian are a bit rusty.

Additional Skills and Services:

Expert is able to give seminars on various topics dealing with carbohydrate chemistry.

Supplier and Vendor Location and Selection

He has experience locating vendors of complex carbohydrate derivatives, and carbohydrate literature.

Other Skills and Services

It is a well-known fact that an hour in a library can save a chemist a month of work in the laboratory. Thirty years of hands-on experience in carbohydrate chemistry and editorial work for a number of international and national scientific journals have made Expert an expert in the literature related to carbohydrates. He is familiar with journals, monographs, and series of books dealing with carbohydrate chemistry. As such, he can be very helpful in assisting individuals in their literature searches and in directing them to the proper source of information in a time-saving manner.

Expert completed a training management program in the chemical synthesis of oligonuleotides at City of Hope Research Institute, Duarte, CA in 1981.


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