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 Expert  722071

Expert in Genomics

Available for your Consulting and Expert Witness Needs

Massachusetts (MA)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

Expert worked with a team that cloned and expressed the enzyme T4 endonuclease VII for commercial distribution. He developed the basic assay of enzyme activity that was used in optimization and quality control of the enzyme. He is an author on two patents related to the product. Expert received SBIR funding for other projects, and developed a diagnostic kit. As an expert in MALDI-TOF analysis of nucleic acids, Expert has worked with several companies to perfect QC systems in their production processes.



molecular biology


molecular genetics


molecular genetics testing

Expert started a clinical genetics lab at the Carolinas Medical Center. The lab made fee-for-service molecular diagnostics of cystic fibrosis and several other genetic diseases. He also manufactured fluorescent probes for cytogenetics. He was the director of new assay development at the Genzyme Genetics DNA Lab, and improved processes for DNA extraction and quality control.

clinical genetics

Expert has wide experience with DNA and applications. He has made extensive sequencing, cloning and expression experiments. He has synthesized DNA with ABI and other instruments. He is an expert on DNA hybridization kinetics, and DNA sequencing by fluorescence and chemical cleavage methods. He is also an expert in mass spectrometric analysis of DNA, and has a passing experience with NMR analysis of DNA. Expert developed several probe technologies and holds two patents on processes in the field. In addition, he developed a novel method for heteroduplex analysis called a heteroduplex generator, for which he received over a million dollars in federal and state grant funding. He has developed probes for human papillomavirus, human genetic diseases (including cystic fibrosis, Factor V leiden, and Bloom's Syndrome). Also, Expert developed a novel method for rapid genotyping using MALDI-TOF MS.



DNA technology


DNA probe technology


recombinant DNA technology

Expert was part of a team in Germany that first described the human cytomegalovirus transcription enhancer element. Expert did primary sequencing and developed a gel shift assay to identify factors associated with the enhancer element. He also discovered other elements in the virus DNA associated with initiation of transcription by RNA polymerase III using a run-off type assay.

gene expression

Expert holds a Ph.D. in medical microbiology and a Master's in applied microbiology. He has extensive research experience with E. coli, bacteriophage phi X 174, the Epstein-Barr virus, human cytomegalovirus, human papillomavirus and bacteriophage T4. He designed DNA tests for all these organisms plus expression cloning in Pichia pastoralis. He has experience in electron microscopy, DNA hybridization, cloning, PCR, RNA extraction, mass spec, and DNA sequencing. In addition, he has some experience with antibody production and protein analysis.


Expert developed several genotyping methods, and has experience in the practice of high through-put genotyping. Expert pioneered a method using heteroduplex generator, and received more than a million dollars in grant funding to make a large scale study genotyping patient DNA in the Rh blood group locus. Expert was the Director of Quality Control for the MASDA genotyping assay at the Genzyme Genetics DNA lab. Over 2000 patient samples a month were processed for up to 100 genotypes each. Expert also helped to provide genotyping data of the human papillomavirus in several large studies.


Expert is an expert in the genetics of the Epstein Barr virus, human cytomegalovirus human papillomavirus, and bacteriophages phi-x-174 and T4. He has several primary publications in these areas. His work was essential in elaborating the genotype/phenotype relationships in EBV regarding the natural history of the virus. Expert worked with the team that discovered and characterized the enhancer element of hCMV. Expert worked with several groups to help define type specific differences in early antigen expression in human papillomavirus.

microbial genetics

Expert recently made a sabbatical year with the Richert Research group at Tufts University. During this time, he learned essential skills for MALDI-TOF MS in the context of nucleic acid and protein analysis. His research work on high-throughput genotyping was published in Nature Biotechnology. He currently serves as the Senior Genomics Scientist at Bruker Daltonics, and has experience in the analysis of nucleic acids and proteins by ion trap and electrospray methods in addition to MALDI. He has several publications in regard to this work.

mass spectrometry





Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Boston, Massachusetts;  Worcester, Massachusetts;  Springfield, Massachusetts;  Lowell, Massachusetts;  Cambridge, Massachusetts;  New Haven, Connecticut;  Hartford, Connecticut;  Waterbury, Connecticut;  Manchester, New Hampshire;  and Providence, Rhode Island.

Year   Degree   Subject   Institution  
1983   PhD   Medical Microbiology and Immunology   Ohio State University  
1979   MS   Applied Microbiology   Northern Arizona  

Work History:
Years   Employer   Department   Title   Responsibilities

1999 to 2001


Bruker Daltonics




Senior Scientist


Expert has primary responsibility for technology assessment in genomics. He teaches training courses and establishes independent collaborations.

1997 to 1999


Genzyme Genetics




Director of Assay Development


He was the Director of new assay and technology validation for the clinical lab.

1993 to 1997


Avitech Diagnostics


R & D


Senior scientist


He developed new genomics technologies, specifically mismatch recognition systems.

1988 to 1992


Carolinas Medical Center


Obstetrics and Gynecology


Director of Molecular Biology


He started a new lab with research and fee for service functions.

Career Accomplishments:

Expert is a member of ASMS and ASHG.

Publications and Patents Summary

He has 54 publications and 2 patents.

Selected Publications and Publishers  
 - Nature Biotechnology  
 - Journal of Biological Chemistry  
 - Pharmacogenomics  

Consulting Services:
Selected Consulting Examples:
  • Expert was named to a CDC genetic testing expert commission.
  • He testified as an expert witness on DNA testing in a criminal trial.
  • He was used as a site inspector by Microbiological Associates in administering a grant for the NIAID.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Expert was an expert witness in federal court on the subject of DNA testing.
Recent Litigation Client Requests:
  • Expert witness on genetic disease research and formulations review for litigation case.
  • Expert for consulting on microarray patent litigation.
  • Electron microscopy expert for consulting on electron microscopist to perform pathology tests.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
2000 to 2000   Germany   Expert participated in a company training.
1983 to 1986   Germany   He was awarded a post Doctoral fellowship in molecular virology in Erlangen, Germany.

Language Skills:
Foreign Language   Description
German   He is conversational in German.

Additional Skills and Services:

He developed training in molecular biology for high school teachers.

He performs a training course in mass spectrometry for Bruker daltonics.


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