ORC Expert Advisory Services ORC International

  home    |    find an expert    |    request an expert    |    join our network    |    about us     expert login  
Expert Consulting and Expert Witness Services
  search tips 
Share this page:  Send to LinkedIn Send to Facebook Tweet This Email Print

 Expert  722397

Expert in Gene Expression, Genomics, Microarrays, DNA, Drug Discovery, Product Development

Available for your Consulting and Expert Witness Needs

California (CA)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise: Listed with other top experts in: 
Expert has worked in the biotechnology industry for more than 30 years. He has directed R&D efforts in gene expression technology, genetic engineering technology, DNA microarrays, and high-throughput screening at Sandoz (Novartis), Operon, Agraquest, GenoSpectra and Expert's Firm. He has led product development efforts for more than 15 years. His efforts have resulted in the introduction of over 50 products to the market.

Expert has worked with nucleic hybridization and DNA techniques for more than 25 years. This includes DNA oligonucleotide synthesis and probe design for oligonucleotide-based DNA microarrays. During his tenure at Operon Technologies he and his research group conceived of and developed oligonucleotide longmers (70 mers) for DNA microarray use. He and his collaborators in Scotland were one of the first groups to develop quantitative RT/PCR techniques for analyzing RNA splicing. He has publications on in situ, filter-based and DNA chip based nucleic acid hybridizations.

He has been working on developing drugs and discovery tools for twelve years at Operon, GenoSpectra and Expert's Firm. This work includes DNA microarrays, high-throughput screening technology and quantitative gene expression technology. He taught a one-day intensive drug discovery and development course at the University of California, Berkeley Extension for several years. He also has taught a one-day course on the power of DNA microarrays. He is currently involved in clinical trials with a cardiovascular protein drug that reduces inflammation and stabilizes vulnerable plaque that is delivered locally.

Expert's group at Sandoz was one of the first groups to effectively genetically engineer corn to be resistant to insects. He holds key patents in corn transformation and a gene expression plasmid construct of Bacillus thuringiensis (Bt) endotoxin. Most of the Sandoz (now Syngenta) insect-resistant transgenic corn lines utilized this technology. Expert and his group also did intensive work on intron-mediated enhanced expression in corn cells. This work is not only key to Bt expression in corn but is routinely used in expressing heterologous genes in mammalian cells. He and his lab also assisted in developing technology to identify these genetically engineered organisms.

Expert's initial training in graduate school was in genetics in the lab of Michael Cummings, author of the textbooks “Concepts of Genetics,” “Essentials of Genetics,” and “Human Genetics.” He has taught genetics for more than 10 years at the University of Illinois, Santa Clara University and at the University of California, Berkeley Extension. His research has dealt with cytogenetics, developmental genetics, drug development and molecular genetics.






DNA technology


drug product approval




genetic engineering


genetically engineered material


plant biotechnology


plant genetic engineering

Expert's R&D work and interests have always revolved around eukaryotic genes and their regulation of expression. His work in this area includes heat shock gene expression, developmental regulation of gene expression, intron-mediated enhanced expression in heterologous systems, and codon-optimized gene expression in heterologous systems. He has more than 24 years of experience in these areas. He has also developed protein production systems to produce recombinant protein drugs.

Expert has been performing research and development in the area of genomics and genome biology for the last eight years. As mentioned in his paragraph on DNA technology, he and his lab group developed DNA microarray probe technology at Operon that included the design and manufacture of genomic sets of 70 mer oligonucleotides for expression profiling for the human, mouse, rat, yeast, Mycobacterium, Drosophila, Arabidopsis, C. elegans, Candida and other genomes.

Expert led product development efforts at Operon Technologie Genospectra, Inc. and Expert's Firm at the Vice President level. He was responsible for putting into place a product development process and the project management oversight to assure on-time introduction of the products. He was involved in product development efforts at the Project Manager/Senior Staff Scientist level at Sandoz. Altogether he was involved with the introduction of over 50 products into the biotechnology market. These products include DNA microarray genomic sets, related products, and transgenic corn plants at Sandoz. The R&D cycles of these products ranged from three to six months to seven years.

Expert is currently serving as the Chief Scientific Officer and Vice President at Expert's Firm where they are developing a novel cardiovascular protein drug that reduces inflammation and stabilizes and reduces vulnerable plaque in arteries. This project is ready to enter clinical trials. He designed and developed recombinant protein production systems that are capable of producing this bioactive protein is a cost effective manner. He also developed protein purification methods to isolate this protein effectively.


eukaryotic gene


eukaryotic molecular biology




gene expression


gene expression regulation


molecular biology


plant molecular biology


recombinant DNA technology






molecular genetics


new consumer product development


drug development

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Sacramento, California;  Stockton, California;  Citrus Heights, California;  Roseville, California;  Davis, California;  Lodi, California;  Folsom, California;  Reno, Nevada;  and Sparks, Nevada.

Often requested
with this expert:

Bioenergy, Renwable Energy, Bioproducts, Agricultural...
Biotechnology, Biochemistry, Molecular Biology: Enzymology,...
Plant Pathology
DNA Technology, PCR, Human Identification, Diagnostics,...

Year   Degree   Subject   Institution   Honors
1978   Ph.D.   Molecular Biology   University of Illinois  
1974   M.S.   Biological Sciences   University of Illinois  
1970   B.S.   Biological Sciences   University of Illinois  
1997   Certificate   Business Management   University of California Berkeley   with Distinction

Work History:
Years   Employer   Department   Title   Responsibilities

2009 to 2015


(Undisclosed Consulting Company)


Research and Development


Chief Scientific Officer And Vice President


Expert serves as the Chief Scientific Officer for Expert's Firm and is largely responsible for its assay development work, ApoA 1 protein production scale up and vector optimization. He has extensive experience in designing, conducting and supervising complex in vitro and in vivo experimental programs

2002 to 2015


(Undisclosed Consulting Company)





Provides consulting in the areas of gene expression, DNA microarrays, product development, and associated DNA technology

2004 to 2009


Lake Tahoe College and Ohlone College




Associate Professor


Taught Biology, Biotechnology and Microbiology. Also served as Director of Biotechnology at Ohlone College.

1993 to 2005


University of California, Berkeley






He teaches molecular biology, drug discovery, and genetics to biotechnology and associated professionals. In addition, at Santa Clara University, he taught general genetics to biology majors for two terms.

2001 to 2002




Product Development


Vice President


His responsibilities included: overall project management for R&D; business development issues involving ancillary products; marketing; marketing research; establishing beta sites for new product assessment; technical and customer service; quality assurance; and customer acquisition.

1995 to 2001


Operon Technologies


Scientific Affairs


Vice President (final position)


As Vice President he was responsible for the Microarray Business Unit, the science involved in new product research and development, the technical aspects of business development, and the establishment and maintenance of extramural research projects. He previously served as Director of R&D and Marketing Manager; and before that as product manager for gene synthesis and as the production manager of gene synthesis.

1994 to 1995






Vice President


He was one of the founders and Directors of a new business venture that involved high-throughput screening for natural products used as bioactive molecules. As VP of R&D, his responsibilities included the setting up of the research laboratories, the hiring of scientific staff, and providing overall scientific leadership. He also led the initial venture capital fundraising effort.

1982 to 1994






Associate Director & Senior Staff Scientist


His responsibilities included the direction of a gene expression project (five to eight scientists), the supervision and direction of the transformation project which included 15-20 scientists and to act as deputy research director in the Director's absence. He served as the Institutional Biosafety Committee (IBC) Chair and as liaison to the California Industrial Biotechnology Association (CIBA).

Career Accomplishments:

He holds a Certificate in Business Administration from the University of California, Berkeley Extension.


Expert was a Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellow and an NIH Postdoctoral Fellow. He received the Presidential Award while at Sandoz, Inc.

Publications and Patents Summary

He has more than 65 publications, abstracts, and presentations, and three issued patents.

Selected Publications and Publishers  
 - Oxidative Stress & Aging: Advances in Basic Science, Diagnostics & Intervention  
 - In Methods in Molecular Biology. Humana Press  
 - Dev. Genet.  
 - Progress in Nucleic Acid Research and Molecular Biology, W.E. Cohn and K. Moldave, Eds.  
 - Drug Discovery World  

Consulting Services:
Selected Consulting Examples:
  • Expert has assisted in recoding and designing genes to be expressed in heterologous systems by codon optimization and avoiding the use of specific inhibiting nucleic acid sequences. Expression levels of the proteins were raised 10- to 100-fold.
  • He made critical suggestions in vector and promoter design that led to stable and ample expression in transgenic organisms expressing heterologous genes.
  • His oligonucleotide design suggestions led to the development of DNA microarrays that yielded consistent and specific expression analysis results. This allowed the development of a platform to be used in clinical research analysis of gene expression in cancer systems.
  • He has advised clients on DNA microarray technology, oligonucleotide design and nucleic acid hybridization as it pertains to intellectual property and basic research and development.
Recent Client Requests:
  • Expert in Gene expression analysis.
  • Early development pharmaceutical industry expert involving gene expression.
  • Expert in new product development to provide input into launch of disruptive qPCR technology.
  • Expert in Packaging RNA for consulting on refining product strategy.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Expert has participated in depositions involving patent disputes.
Recent Litigation Client Requests:
  • Expert for consulting on microarray for litigation.
  • Mycobacterium expert for consulting on MAC.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Market Research:
Expert has been responsible for bringing to market more than 30 biotechnology products that have revenues ranging from $10,000 to more than $100 million. He ran the marketing effort at Operon technologies for two years and supervised the market development thrust at GenoSpectra.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:

Expert has taught "Drug Development": a one-day intensive overview of the drug development process. He has also taught "DNA Microarrays": a one-day intensive course about the design, fabrication, and use of DNA microarrays. He continues to teach a two-semester molecular biology course and a genetics course at the University of California, Berkeley Extension.

Supplier and Vendor Location and Selection

He has extensive experience and knowledge in synthetic DNA synthesis and knows the strengths and weaknesses of the various vendors who make custom DNA.


Need the right expert?  We can help!

home       find an expert       request an expert       join our network       about us

Intota is now ORC Expert Advisory Services