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 Expert  722843

Expert in Drug Delivery Using MEMS, Ultrasound, Electroporation and Other Engineering Technologies

Available for your Consulting and Expert Witness Needs

Georgia (GA)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise: Listed with other top experts in: 
Expert has been the founder of two novel fields of transdermal drug delivery and has led a paradigm shift from chemical to physical methods to enhance skin permeability. He published the first paper establishing electroporation of skin. Using this approach, short, high-voltage electric pulses are applied to the skin to rearrange the molecular structures that form the skin barrier by a mechanism related to dielectric breakdown of capacitors. Expert also invented another physical method to increase transdermal transport and published the first paper on microneedles in 1998. Expert has intensively studied fundamental issues associated with mechanisms of drug transport across skin, skin-needle biomechanics, and avoidance of pain; and has pushed applications forward by developing novel microfabrication technology to make microneedles and new methods to deliver drugs in controlled and targeted ways.

Anther major topic of Expert' research has been intracellular drug delivery using ultrasound and electroporation. Expert has intensively studied and produced by far the largest dataset establishing the relationship between acoustic and other experimental parameters and the effects of ultrasound on intracellular delivery and cell viability in vitro. He has also developed and patented novel feedback strategies based on acoustic and optical emissions produced during ultrasound exposure for real-time control of biological effects. Most significantly, he has elucidated the mechanism by which ultrasound acts on cells, where cavitation bubbles associated with ultrasound mechanically detach micron-scale sections of membrane from cells, which in turn actively reseal these wounds using endogenous lipid vesicles. Expert has also made important advances in electroporation of tissues and cells as a means to deliver molecules across cell membranes in a targeted manner. His work has produced the first studies of electroporation of polarized epithelium and tumor spheroids, which provides a critical link between in vitro cell suspensions and in vivo tissues. Expert also produced a set of widely applicable and validated mathematical expressions to predict conditions that optimize DNA transfection using electroporation.

Expert also works on drug delivery to the eye to model drug diffusion across ocular barrier tissues and to experimentally study drug delivery to the back of the eye. In addition to teaching a sophomore-level Chemical Process Principles class, Expert developed two new courses. He first developed “Effective Communication for Professional Engineering,” which emphasizes the skills needed to accomplish realistic workplace goals through oral and written communication. Expert' second new course entitled “Drug Design, Development and Delivery” provides an integrated, interdisciplinary analysis of the design, development and delivery components of pharmaceutical science.


controlled-release drug delivery


dermal absorption


drug delivery


electrotransport drug delivery






ocular drug delivery


skin absorption


skin permeability coefficient


skin permeation




transdermal drug delivery


transdermal patch


ultrasonic cell disruption


ultrasound biological application

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Atlanta, Georgia;  Columbus, Georgia;  Athens, Georgia;  Macon, Georgia;  Roswell, Georgia;  Marietta, Georgia;  and Chattanooga, Tennessee.

Often requested
with this expert:

Dermal Drug Delivery
Biomaterials and Product Development R&D for Orthopedic,...
Composite Materials
Microbiology, Biotechnology, Cleanroom Microbiology,...

Year   Degree   Subject   Institution  
1994   Ph. D.   Chemical and Biomedical Engineering   MIT  
1988   B. S.   Chemical Engineering   Stanford University  

Work History:
Years   Employer   Department   Title   Responsibilities

1995 to




School of Chemical and Biomolecular Engineering


Associate Professor


Expert heads the Laboratory for Drug Delivery, which houses 12-15 graduate and postdoctoral researchers. He also teaches undergraduate and graduate courses on pharmaceuticals, technical communication, and engineering principles. He is the Director of the Center for Drug Design, Development and Delivery, with 25 faculty participants.

Career Accomplishments:
Professional Appointments

Expert serves on the: Editorial Advisory Board, Journal of Controlled Release; Editorial Advisory Board, Pharmaceutical Research; Advisory Board, Center for Drug Delivery Research, Southern School of Pharmacy at Mercer University; Scientific Advisory Board, CytoDome, Inc.; and the Board of Directors, Redeon, Inc.


He has received or has been named: the Young Investigator Award, Controlled Release Society; Curtis W. McGraw Research Award, American Society for Engineering Education; NSF/NIH Scholar-in-Residence at the National Institutes of Health, National Science Foundation; 40-Under-40 Rising Stars of 2001, Georgia Trend Magazine; Finalist, Coulter Award for Innovation and Entrepreneurship, The Wallace Coulter Foundation; BP/AMOCO Junior Faculty Teaching Excellence Award, Expert's Firm; Top 100 Young Innovator (TR100), Technology Review Magazine; Student Paper Competition Award, Advisor, Science Applications International Corporation; Junior Faculty Research Award, Sigma Xi Scientific Research Society, Expert's Firm Chapter; CAREER Young Investigator Award, National Science Foundation; Best Paper Award, Journal of Clinical Engineering; Outstanding Pharmaceutical Paper Award, Controlled Release Society; and the Outstanding Work in Transdermal Drug Delivery Award, Controlled Release Society.

Publications and Patents Summary

Expert has 70 journal publications, 85 invited presentation at conferences, companies and academia, and 100 conference abstracts.

Selected Publications and Publishers  
 - Nature Reviews Drug Discovery  
 - Proceedings of the National Academy of Sciences  
 - Ultrasound in Medicine and Biology  
 - Pharmaceutical Research  
 - Journal of Controlled Release  

Government Experience:
Years   Agency   Role  
1995 to   NIH, NSF, other   Grant Proposal Reviewer  

Consulting Services:
Recent Client Requests:
  • Expert in electroporation for consulting on high impedance electroporation (field generation w/o conducting current).
  • Expert on FDA regulations relating to non-drug topical and transferal patches.
  • Expert in a dermatology drug delivery for Rx derm products.
  • Expert in formulation chemistry for consulting on dermal patch for cosmetics.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Expert has served as expert witness in the following cases: 1). Iomed v. Yanaki, et al., Third Judicial District Court, Salt Lake County, UT (Case No. 020903031); retained by defendant (Parsons Kinghorn Peters); provided an expert report on confidential information and trade secrets. 2). SpectRx, Inc. v. Non-Invasive-Monitoring Co. et al., American Arbitration Association, Atlanta, GA (Case No. 301600015400); retained by plaintiff (King & Spalding); provided an expert report, deposition, and testimony on interpretation of a license agreement and patents. 3). Retained by plaintiff (Thomas William Malone, P.C.); Began preparation of an expert report on medical device operation.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
1994 to 1995   Asia, Africa, Latin America, and the Carribean   Expert worked for ORBIS International developing and implementing a biomedical engineering training program in China, Myanmar (Burma), Sudan, Jamaica, El Salvador, and Peru.

Additional Skills and Services:
Other Skills and Services

He has consulted for the following companies: CytoDome, Tucson, AZ; GMP Companies, Fort Lauderdale, FL; The Mentholatum Company, Ltd., Glasgow, Scotland; Corixa, Inc. Seattle, WA; The Washington Advisory Group, Washington, DC; Unilever Research U.S., Edgewater, NJ; Valentis, Inc., The Woodlands, TX; Redeon, Inc, Cambridge, MA; EKOS Corporation, Bothell, WA; Becton Dickinson, Franklin Lakes, NJ; Genetronics, San Diego, CA; ALZA Corporation, Palo Alto, CA; Genentech, Inc, South San Francisco, CA; Myanmar Ministry of Health, Yangon, Myanmar (Burma); Pharmos Corporation, Rehovot, Israel; and Health Advances, Wellesley, MA.


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