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 Expert  723721

Expert in Biomedical and Pharmacokinetic Modeling and Programming

Available for your Consulting and Expert Witness Needs

Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

Expert has performed experimental work in biochemistry for his doctoral thesis. This work included isolation of mitochondria from Neurospora crassa and rat liver, isolation and purification of membrane proteins by electrophoresis and reverse-phase chromatography, gel electrophoresis and use of radioactive tracers to label membrane proteins. Expert has performed experimental research in the uptake and metabolism of substrates using the perfused rat liver and the dog liver in vivo, using mainly the multiple indicator technique.



biochemical research



Expert performed experimental work pertaining to the uptake and metabolism of drugs and substrates in the whole organs (mainly perfused rat liver and dog live in vivo) using the multiple-indicator dilution technique. This included the preparation of radioactive tracers to be applied to the organ and analysis of blood samples by ion-exchange chromatography, gamma spectroscopy and liquid scintillation spectroscopy. Expert has analyzed these results using mathematical models including mass transport and metabolic transformation. Expert has also analyzed pharmacokinetic data for several contract research organizations.



drug development


drug metabolism

Expert has written and applied specialized software for the simulation of mass transport and metabolism. This software was used for the evaluation of experiments using mainly the multiple indicator technique, a method for investigation uptake and transport of substances in whole organs by means of radioactive tracers. The software was written in FOTRAN (9000 lines). Expert participated actively in the development and maintenance of simulation software "JSim", written in Java and FORTRAN. JSim is a Java-based simulation system for building quantitive numeric models and analyzing them with respect to experimental reference data. Expert has knowledge of most major programming languges.

application software


FORTRAN programming language




Macintosh programming


simulation software


ALGOL programming language


computer spreadsheet


Microsoft Visual Basic


UNIX application


pharmacokinetic modeling

Show Secondary and Basic Areas of Expertise

Year   Degree   Subject   Institution   Honors
1971   Dr.rer.nat (PhD equivalent)   Biochemistry   Ludwig-Maximilian-Univ Munich   sehr gut (magna cum laude)
1968   Diplom (MSc equivalent)   Chemistry   Ludwig-Maximilian-Univ Munich   sehr gut (magna cum laude)

Work History:
Years   Employer   Department   Title   Responsibilities

1985 to


(Undisclosed University)


Research Institute


Medical Scientist/Associate Professor


Experimental work in radioactive tracers, modeling and simulation of haptic tranport and metabolism. Supervision of technicians and programmers.

1988 to 1988


University of Toronto


Faculty of Pharmacy


Rosenstadt Professor (visiting)


Experiments using the multiple indicator dilution method and mathematical analysis of the results

1971 to 1985


Ludwig-Maximilian University Munich


Physiological Chemistry


Scientific Assistant/Research Scientist


Experimental work on the biogenesis of mitochondria; Experimental work, modeling and simulation of haptic tranport and metabolism; Programming of simulation software in Fortran and Algol; seminars and experimental workshps in biochemistry for pre-clinical medical students.

Career Accomplishments:

American Physiological Society, Microcirculatory Society


1982 Habilitation (Dr.med.habil.) in physiological chemistry at the Medical Faculty, University of Munich


1988 Rosenstadt Professor of the University of Toronto (visiting)

1985–1987 Deutsche Forschungsgemeinschaft Senior Research Fellow

Publications and Patents Summary

63 publications in peer-reviewed scientific journals, 15 book chapters

Selected Publications and Publishers  
 - Parasitology  
 - Basic Research in Cardiology  
 - American Journal of Physiology  
 - Environmental and Health Perspectives  
 - The Liver: Biology and Pathobiology  

Government Experience:
Years   Agency   Role   Description
1994 to   National Institutes of Health   Ad-hoc reviewer   Reviewing applications for funding at the Respiratory and Applied Physiology Study Section
1999 to   National Institutes of Health   Ad-hoc reviewer   Reviewing applications for funding at the General Medicine Special Study Section.

Consulting Services:
Selected Consulting Examples:
  • Programming of software for evaluation of enzyme kinetics for a research contract organization
  • Evaluation of pharmacokinetic data for two research contract organizations
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
1966 to 1967   Venezuela   Experimental work in heterogenic catalysis for diploma thesis

Language Skills:
Foreign Language   Description
German   Geman is the Expert's first language and the language of his education
French   Expert has learned French as a child and is using it daily as a resident of Quebec
Greek   Greek is the expert's mother tongue. Expert has translated technical texts from Greek to English.
Spanish   Expert used Spanish during his year-long visit to Venezuela including for work.

Additional Skills and Services:
Other Skills and Services

Programming of simulation software, participation in the devolopment of JSim


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