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 Expert  724265

Expert in Neuropharmacology, Aging, Brain Injury, Memory Impairments, Imaging, Neurodegenerative Disorders

Available for your Consulting and Expert Witness Needs

Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise:

Listed with other top experts in: 

Expert has worked on several projects involving Alzheimer's disease (AD). In particular, he has used genetically engineered mouse models to test ideas and answer questions related to how biological memory might be affected by AD pathophysiology. In addition, he has looked at the role of several molecules that may play a role in AD, including, NF-kB, sAPP, amyloid plaques, CREB, to name a few. He has also published several important manuscripts in high-impact peer-reviewed medical journals on memory and Alzheimer's disease. To his credit he has been funded multiple times on projects associated with Alzheimer's disease, dementia, and memory impairments.

Expert is considered an expert when it comes to using a variety of different animal models of CNS disease or brain injury. In particular, he has used animal models (rats, mice) to simulate stroke, traumatic brain injury (TBI), epilepsy, Alzheimer's disease, and even memory disorders. These models include: fluid-percussion, cortical impact, cortical ligation, long-term potentiation (LTP), Morris water maze (MWM), and the Barne's maze, etc. Transgenic strains have included, PS1-M146V, CRND8, p50 KO, 3X Tg, etc. The models have also been used to test novel drugs, natural products and to investigate mechanisms of CNS disease.

Expert has extensive experience in both academia and industry where he has used a variety of animal models to test standard drugs and also novel compounds. For the most part these methods were performed in order to test drugs in models of CNS disorders. The analyses have included behavioral, electrophysiological, MRI, and histological, etc. In addition, he has worked with a variety of age groups from neonatal to aged models. Compounds have included NMDA antagonists, natural products (spider, snake, and scorpion venom), antioxidants, etc.

Expert is a Pharmacology Professor and has taught several classes in the past on drug action, classification, and mechanisms, etc. These classes have included medical, graduate, and nursing students. In these classes he has lectured on the basics of anticonvulsant drug therapy, classification of anticonvulsant drugs, and drugs improving or affecting memory. In addition, he has experience in the industrial sector in both clinical trials and preclinical drug screening. Expert has also used a variety of anticonvulsant drugs for his research. In addition, he is considered an expert on drugs that affect the NMDA receptor, a protein receptor involved in normal physiology, memory, normal aging, CNS disease, and brain injury.

Expert has a PhD in Neuroscience from the University of Utah's School of Medicine. In addition, he has received advanced training on brain biology at a number of internationally recognized institutes. A majority of his past and current work focuses on brain function and brain disease. He has also been a course director in classes focused on General Neurobiology.


Alzheimer's disease




biological aging




animal disease model


animal drug testing


new drug


anticonvulsant drug




molecular pharmacology












central nervous system






central nervous system disease

Expert has extensive experience in both drug development (Pfizer, Warner-Lambert) and in preclinical drug discovery (NPS Pharmaceuticals). In particular, he attended over 30 classes while at Pfizer (Ann Arbor. MI) on topics associated with drug development, clinical trials, clinical monitoring, and adverse events, etc. In addition, he served in the clinical research department while at Pfizer working on Clinical Trials. This involved extensive medical writing in order to produce documents such as: investigational new drugs (IND), investigator's brochures, safety reports, clinical research reports, etc.

Expert has conducted several animal studies in the past concerning the use of novel electrical stimulation for seizure control. His work has been published in several high impact journals where he has shown differences between low vs. high frequency stimulation protocols with regard to seizure attenuation effectiveness. In addition, he has investigated mechanisms of action associated with the beneficial effects of electrical stimulation in animal models of epilepsy.

Expert has spent over 12 years using methods involving in vitro electrophysiology. These techniques have included intracellular, extracellular, and patch-clamp recording configurations in a variety of rodent and bird models. In addition, he has recorded in vitro from human brain tissue resected from human epilepsy patients at the Cleveland Clinic. This technique has been applied for questions related to epilepsy, Alzheimer's disease, dementia, memory disorders, head trauma, and stroke, to name a few. Also the technique has been used for testing novel drugs. The expert also tutors/instructs medical and graduate students on topics in the area of membrane biophysics.

Expert is considered an expert with several types of neuroimaging methods. In particular, he has used MRI in rodent models for evaluating the progression of head trauma and stroke. In addition, he has tested a variety of novel drugs using this method to determine efficacy and regional specificity. Moreover, he has used a variety of MRI scan protocols including those for standard anatomical imaging (T1, T2, proton density) and also diffusion-weighted imaging (DWI) and functional MRI (fMRI) for physiological based questions and testing. He has several publications in this area.

He is considered an expert with experimental paradigms that simulate biological memory encoding or more scientifically called, synaptic plasticity. Methods such as long-term potentiation (LTP), Morris water maze (MWM), Barnes maze, etc. have been used in conjunction with other cell, molecular, and behavioral techniques for a thorough investigation of plasticity and memory mechanisms during normal memory processing and also under conditions of brain disease or injury.


drug development


clinical research


clinical study


clinical trial


clinical trial design


documentation process


electrical medical treatment




clinical neurophysiology




cell membrane biophysics


magnetic resonance imaging




memory disorder

Expert has worked on mechanisms involving glutamate (glutamic acid) neurotransmission for almost 20 years. Glutamate is of course a very important molecule not only for normal synaptic transmission (binds to NMDA and AMPA receptors), but plays a role in normal memory, memory disorders, CNS disease, and CNS injury. Increases in glutamate, go hand-in-hand with increases in intracellular calcium. He has published extensively in this area and has written several important reviews associated with this topic (e.g.., NMDA receptor functioning).

Expert has published or has in press over 85 scientific articles on topics involving the CNS, brain injury, memory, neuroimaging, aging, drugs, and neurodegenerative diseases, such as Alzheimer's and epilepsy, etc. This includes 20 peer-reviewed papers, 5 peer-reviewed proceedings, 3 book chapters, 15 monographs/collective works, 40 abstracts, and 4 clinical trial reports. In addition he has at this writing (Oct 2007) 5 manuscripts in preparation. He also has extensive editorial service including being an editor on a new book (Nova Science Publishers, Inc.). Moreover, expert has written many successful grant applications (12 to date) and has received funding as PI, co-PI, or co-applicant from the CIHR, NSERC, MMSF, MHRC, Scottish Rite Found., Bayer co., to name a few. He also has served or currently serves on several grant review panels including the NIH (SBIR, RO1, R29 grants, etc.), CIHR, Alzheimer's Assoc. (USA), Alzheimer's Soc. (Canada), AIBS, and CRDF, etc. Furthermore, expert has received formal training in technical/medical writing from Pfizer (Warner-Lambert) and ProEd Healthcare Comm. Finally, he has served as an editor on a number of newsletters and currently is an ad hoc reviewer for several well known medical journals. Examples of other clinical documents that he has prepared include: safety reports/updates, investigator's brochure, research reports, investigational new drug (IND) application, etc.

He also has taken over 10 classes in computer programming, which include: Classes in C/C++, UNIX, BASIC, FORTRAN, NEURON, AutoCAD, SPSS, Documentum, & Computer Graphics (used BASIC). Knowledge of UNIX, DOS, Windows 95, XP, & Mac OSs and SUN, SGI, & IBM PC workstations. Experience with MS Office, Lotus 123, XV, NIH-Image, Visual Basic, SMIS, FrameMaker, AutoCAD, PowerPoint, Matlab, Origin, ParaVision, SPSS, WinTrack, Voxel View, AXOSCOPE, Axon pClamp, NEURON, LabVIEW, BioCell, WinWCP, CorelDRAW, & Minitab programs.


glutamic acid






report writing


SBIR grant writing


technical writing




proposal writing


technical editing


computer programming


cognitive disorder

Show Secondary and Basic Areas of Expertise

Year   Degree   Subject   Institution   Honors
1995   PhD   Neuroscience   Univ. of Utah  
1992   MA   Biology   Sonoma State Univ.  
1982   BS   General Science   Univ. of Oregon  
1999   Postdoctoral Scholar   Department of Anatomy & Neurobiology and Aging   Sanders-Brown Research Center on Aging (Alzheimer's Disease Research Ctr.) and University of Kentucky Medical Center   Advisor: Dr. Mark Mattson
1997   Postdoctoral Fellow   MRI, trauma, neuroprotective drugs   Georgetown Univ. - Inst of Cognitive & Compuational Sci.   Advisors: Drs J. Pekar and A. Faden

Work History:
Years   Employer   Department   Title   Responsibilities

2005 to




Pharmacology & Therapeutics


Associate Professor


Faculty, research (95%), teaching, administration, service

2005 to




Divn of Neurodegenerative Disorders


Principal Investigator


Research (95%), teaching, administration, service

2003 to 2004


Case Western Reserve University




Adjunct Assistant Professor


Course director, teaching

2001 to 2004


The Cleveland Clinic Foundation


Dept. of Neurological Surgery


Project Staff ( Research Assistant Professor)



1999 to 2001


Pfizer Global Research & Development, Inc


Clinical Research Dept.


Clinical Research Contractor


Clinical trials team, safety reports, investigator's brochure, new drug application, clinical research reports

1987 to 1991


Natural Product Science Pharmaceuticals, Inc


Research Dept.


Research Associate (predoctoral)


Preclinical research, electrophysiology, data analysis, report writing, poster presentations

1986 to 1987


Multi-Tech Labs, ETTC


Inorganic Chemistry Dept.


Analytical Chemist (pre-doctoral)


Bench chemistry, wet chemistry, inorganic chemical analyses, microbiology testing, environmental testing, water samples, waste samples

Career Accomplishments:

Centre on Aging, University of Manitoba, Membership status: Research Affiliate American Society for Pharmacology & Experimental Therapeutics (ASPET), Manitoba Inst. of Child Health (MICH), Membership status: Scientist, Spinal Cord Res. Ctr., Univ. Manitoba, Membership status: Associate Member, Canadian Association for Neuroscience, Pharmacological Society of Canada, Institute of Electrical & Electronics Engineers (IEEE) Computer Society, American Physiological Society, American Society for Neurochemistry, American Epilepsy Society, Brain Injury Association, International Neural Network Society, International Society for Magnetic Resonance in Medicine (ISMRM), International Brain Research Organization (IBRO), American Association for the Advancement of Science (AAAS), Society for Neuroscience


Certificate in Management - Univ. of Utah

Professional Appointments

Assistant Professor - Expert's Firm Principal Investigator - Expert's Firm Scientist - Manitoba Inst. of Child Health Research Affiliate - Ctr. on Aging, Expert's Firm


AWARDS & FELLOWSHIPS: Academic Scottish Rite Charitable Foundation of Canada Award Ceremony, Wpg. MB

Manitoba Medical Service Foundation (MMSF) Award Ceremony, Wpg. MB

Manitoba Health Research Council (MHRC) Award Ceremony, Wpg. MB

Expert's Firm Faculty Travel Fund, $1000, Wpg, MB

New Opportunities Fund Award Ceremony, Canada Foundation for Innovation, University of Manitoba, Wpg., MB

NIH - NINDS Travel Award, International Geriatric Epilepsy Symposium, Coral Gables, FL

U. of Kentucky Med. Ctr., Spring Neurosci. Day, 1st Prize-Best Poster (cash award)

Georgetown University Medical Center Research Fellowship

William D. Carey Science Award – American Association for the Advancement of Science

Surrey Medical Imaging Systems Travel Stipend

Medical Imaging Research Lab Symposium, Sundance, UT, Oral Presentation Finalist

Graduate Research Fellowship Award, Univ. of Utah

Industrial Warner-Lambert's Colleague Recognition Award (cash award) Multi-Tech Labs., ETTC Corp., Achievement Award

Biographical Listings 25th Edition- Who's Who in the World 10th Edition – Who's Who in Science and Engineering 62nd Edition - Who's Who in America 9th Edition – Who's Who in Science and Engineering 22nd Edition - Who's Who in the World 8th Edition - Who's Who in Science and Engineering 58th Edition - Who's Who in America 21st Edition - Who's Who in the World 20th Edition - Who's Who in the World 57th Edition - Who's Who in America 19th Edition - Who's Who in the World 3rd Edition - Who's Who in Medicine and Healthcare 17th Edition - Who's Who in the World 51st Edition - Who's Who in America 3rd Edition - Who's Who in Science and Engineering

Medical/Professional Internships

1) Postdoctoral Fellowship at the Inst. of Cognitive & Computational Sciences - Georgetown Univ., Washington, DC 2) Postdoctoral Scholar at the Sanders-Brown Ctr. on Aging- Univ. of Kentucky

Publications and Patents Summary

20 peer-reviewed publications 5 peer-reviewed proceedings 14 collective works 40 abstracts 4 industrial research reports (internal) 1 PhD thesis 1 MA thesis

Selected Publications and Publishers  
 - Synapse  
 - Brain Research  
 - American Journal of Alzheimer's Disease and Other Dementias  
 - Experimental Neurology  
 - Current Pharmaceutical Design  

Government Experience:
Years   Agency   Role   Description
1985 to 1985   California Dept. of Forestry   Inspector   Dutch Elm Disease Project
2001 to 2006   NIH   Panel Member   1) Reviewer of grants (R01, SBIR, R29, etc). 2) Acting chairman of grant panel

Consulting Services:
Selected Consulting Examples:
  • Methods Development -- University of Utah - School of Medicine: established electrophysiology methods in university lab
  • Patent Litigation - Supplied expertise on drugs for Alzheimer's disease. Researched medical journals for case development. Offered advice/clarification on history of drug mechanism of action, etc.
  • Program Development for Pharmaceutical Sales Team. Wrote text for education program for new hires. Also created an audio script for part of the training program.
  • Methods Development - Wrote review article for cell culture methods in collaboration with a major pharmaceutical company (co-authorship).
  • Clinical Trials Report Publications and Other Publications -Assisted in writing clinical trial results, analysis, and interpretation, etc. - for publication. In addition, several manuscripts have been published (client paid) in trade journals focusing on novel drugs and drug signaling pathways. Some ghost review writing has also been done on several novel drugs.
Recent Client Requests:
  • Expert in SBIR grant writing for consulting on SBIR grant proposal.
  • Expert in sbir grant writers for consulting on SBIR Grant writing.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
No court appearances to date. However, he has helped to provide research articles and personal expertise for patent cases.
Recent Litigation Client Requests:
  • Expert witness in Alzheimer's dementia in Utah for consulting on cause of memory loss in trauma incident.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
2005 to   Canada   Professor
1985 to 2004   USA   Pharmaceutical company experience, academia
2005 to 2005   Germany   Invited lecture
2001 to   Spain   Scientific advisor, medical writer

Language Skills:
Foreign Language   Description
English   native tongue
Italian   intermediate
French   beginner

Market Research:
Competitive intelligence reports, scientific marketing (marketing for his consulting services). In addition, Expert, has a certificate in management from University of Utah and several years of experience in the training and supervising of lab personnel.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:

Neuroscience, neuropharmacology, drug action, aging, dementia, epilepsy medications, brain injury (stroke & head trauma), memory medications, cognition, electrical stimulation therapy, general biology, zoology,

Supplier and Vendor Location and Selection

Almost everyday he locates new suppliers for scientific materials for the lab. Expert also belongs to several scientific societies and has considerable networking capability.

Other Skills and Services

Training, lectures, medical writing, grant writing, report writing, editing, competitive intelligence reports, scientific experiments, clinical research, basic preclinical research, clinical trials experience, new drug testing, data analysis, statistical analyses, publishing, poster presentations, new methods development, neuroimaging, photography, video.


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