ORC Expert Advisory Services ORC International

  home    |    find an expert    |    request an expert    |    join our network    |    about us     expert login  
Expert Consulting and Expert Witness Services
  search tips 
Share this page:  Send to LinkedIn Send to Facebook Tweet This Email Print

 Expert  725203

Expert in Immunology, Vaccinology, Infectious Diseases, Recombinant Proteins

Available for your Consulting and Expert Witness Needs

Texas (TX)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise:

Listed with other top experts in: 

Expert has been involved in numerous animal studies examining various aspects of infectious disease agents. Expert has worked with animal models of infection with the following diverse pathogens: Schistosoma mansoni, Candida albicans, Borrelia burgdorferi, and S. aureus. In addition, he has been a part of vaccine design studies aimed at developing vaccine formulations for the preventions of Lyme disease (B. burgdorferi) and S. aureus infections. The findings of these studies have been published in peer-reviewed journals and can be found on routine Pub-Med searches.

Expert was the lead investigator on a CDC-sponsored project to explore candidate antigens for the development of a Second Generation Lyme vaccine. The results from this study have been published in the journal Vaccine. Currently, Expert is involved in a research project aimed at developing a vaccine that can be used to protect against methicillin-resistant S. aureus-induced pneumonia. Both of these research projects involved mouse models of disease. In both models of disease, cellular and humoral responses were measured using ELISA-type assays and measuring the delayed-type hypersensitivity responses to specific antigens following immunization or infection.

Expert has experience with several bacterial models of disease. His early work involved examining the role of ultraviolet radiation (a known immunosuppressant) on bacterial dissemination. Specifically this work was done using the Lyme spirochete Borrelia burgdorferi. He later used the primary disease manifestations caused by this pathogen (arthritis) as a read out for vaccine efficacy in projects developing novel vaccines for the prevention of disease. Expert has used various models of disease to study the mechanisms of immune evasion employed by S. aureus and is currently involved with vaccine research related to preventing staphylococcal disease.

Many disease manifestations resulting from S. aureus infections are a function of toxins produced by this organism. One toxin in particular called the Panton Valentine leukocidin is associated with the methicillin-resistant strains of S. aureus responsible for the current epidemic that primarily affects otherwise healthy children. Expert was part of a team that developed a mouse model to study the effects of this toxin in the development of necrotizing pneumonia. These results are published in Science magazine (2007).

Expert's doctoral work explored the effects of ultraviolet radiation on various immune functions. Ultraviolet radiation is a known immunosuppressant that can suppress both humoral and cellular responses including contact and delayed-type hypersensitivity. Expert used suppression of CHS and DTH in various capacities during his graduate career and understands the effector mechanisms associated with both hypersensitivity responses.

The enzyme-linked immunosorbent assay (ELISA) has been a technique used by Expert in various capacities for over 20 years. ELISA assays were used and are currently being used to assess the type of immune response that develops to various antigens following either infection or immunization.


animal study


infectious disease






animal vaccine


bacterial vaccine


Borrelia infection


humoral immunology








Lyme disease


vaccine development


bacterial disease




bacterial toxin


Methicillin-resistant Staphylococcus aureus


staphylococcal infection


contact sensitization


delayed-type hypersensitivity reaction


enzyme-linked immunosorbent assay

Expert has been involved in various vaccine studies aimed at developing formulations that can protect against Borrelia burgdorferi (the Lyme spirochete) or Staphylococcus aureus, respectively. For each study, recombinant proteins were used as vaccinogens. The genes to each recombinant protein used in the vaccine studies were cloned into respective expression vectors and the proteins generated from this process were purified using affinity chromatography and used in the vaccination experiments. For the different studies, various adjuvants were used to stimulate the immune response depending on the route of vaccination. Intraperitoneal vaccinations included vaccine candidates emulsified with either Freund's complete and incomplete adjuvant, alum, or titermax and intranasal vaccinations were done using Cholera toxin as an adjuvant.

Pathogens use various strategies to escape immune recognition. One common strategy is immunomodulation of humoral or cellular responses (or both). Expert has researched immunomodulation in S. aureus for several years. Specifically, he has shown that the S. aureus Map protein (MHC class II analog protein) can inhibit T cell-mediated responses (delayed-type hypersensitivity) and the Efb protein (Extracellular fibrinogen-binding protein) can inhibit complement-mediated lysis. Both of these proteins are the subject current patent applications that propose the use of these proteins as modulators of the immune response in the context of certain autoimmune diseases.

Expert spent several years working with the trematode Schistosoma mansoni. This helminth is second only to Malaria as a cause of morbidity and mortality in endemic regions and infections begin through the skin and after several weeks adult worms live in the hepatic portal system laying eggs that get lodged in the microvasculature causing tissue destruction. Using ultraviolet radiation (an immunosuppressant that can destroy immune cell in the skin), Expert explored the role of the cutaneous immune system on S. mansoni infections.


immunologic adjuvant


recombinant protein




immunomodulation agent








immune disorder

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Houston, Texas;  Pasadena, Texas;  Beaumont, Texas;  College Station, Texas;  Baytown, Texas;  Bryan, Texas;  Sugar Land, Texas;  Port Arthur, Texas;  Galveston, Texas;  and Missouri City, Texas.

Year   Degree   Subject   Institution  
1996   Ph.D.   Immunology   University of Texas Graduate School of Biomedical Sciences  
1989   B.S.   Biology   Texas A&M University  

Work History:
Years   Employer   Department   Title   Responsibilities

2005 to


(Undisclosed University)


Center for Infectious Disease


Assistatn Professor


Expert's responsibilities include research programs in Staphylococcal and enteric diseases in addition to teaching Parasitology and Medical Microbiology.

2004 to 2005


Wyle Laboratories




Discipline Coordinating Scientist


Expert was a member of the Discipline Coordinating Scientists, a five member team tasked with mapping future grant initiatives for NASA.

1996 to 2005


Texas A&M Health Science Center


Extracellular Matrix Biology


Assistant Professor


Expert's responsibilities included research projects in the areas of vaccine design (developing a second generation Lyme disease vaccine) and staphylococcal disease (understanding immune escape mechanisms of S. aureus).

Career Accomplishments:

American Association of Immunologists

American Society for Microbiology

Publications and Patents Summary

Expert has 28 manuscripts in publication and 2 book chapters and is listed as inventor on 3 patents.

Selected Publications and Publishers  
 - Science  
 - ASM Press--Infection and Immunity  
 - Vaccine  
 - Journal of Clinical Investigation  

Consulting Services:
Recent Client Requests:
  • I need expert veterinary vaccine for consulting on veterinary vaccine.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Texas Senate Committee on Administration, expert witness for issues relating to prevention and treatment of tick-borne illnesses in Texas
Recent Litigation Client Requests:
  • Expert for consulting on Lyme, micotoxin, autoimmmune, ANA, Thyroid.
  • Vaccination expert for consulting on vaccination side effects.
  • Expert in Clinical Laboratory Standards
  • Expert in wake forest microbiology research associate center for environmental medicine environmental monitoring staff immunologist for consulting on Vaccine Litigation.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Language Skills:
Foreign Language   Description
Spanish   Expert was born in San Jose, Costa Rica in 1967 where he was raised speaking Spanish. He attended a bilingual school through high-school before going to the United States for his college and graduate education.

Market Research:
Served on the Scientific Advisory Board Meeting, Inhibitex Inc., Alpharetta, GA in 2003.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.


Need the right expert?  We can help!

home       find an expert       request an expert       join our network       about us

Intota is now ORC Expert Advisory Services