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 Expert  726604

Expert in Bionanosciences, Nanomaterial interfacing & targeting, Cell biology & biophysics, Molecular imaging


Available for your Consulting and Expert Witness Needs

California (CA)
USA
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

The expert has been actively designing and developing surface chemistries and coatings that allow a controlled organic/inorganic interfacing of colloidal nanomaterials with biomolecules. Over the past 14 years, projects carried out by the expert have focused on engineering the surface of 2-20 nm nanostructures to specifically target molecules and structures of interest in living cells and animal models. Using multidisciplinary approaches, the expert has carried research projects all the way from the nanomaterial synthesis and development phase to actual biological applications. His work encompasses the wet-chemical synthesis of colloidal nanostructures, the solubilization, stabilization, and biofunctionalization of inorganic nanomaterials using small organic molecules, thin silica shell encapsulation or custom-designed peptides, the development of specific and high affinity bioconjugation strategies, the physical and biochemical characterization of hybrids nanomaterials by spectroscopy, TEM, AFM, FTIR, chromatography or electrophoresis, and the use of these nanomaterials for biological targeting and imaging in living cells and live animals.
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nanobiotechnology

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nanoparticle

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biosurfactant technology

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fluorescent material

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colloid and interface chemistry

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advanced material

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materials engineering

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nanomaterial

In addition to his expertise in nanomaterials interfacing with biomolecules the expert has extensive experience in single molecule detection, ultra-high resolution fluorescence imaging including super-resolution imaging and single particle tracking in living cells and biological tissues. In particular, the expert continuously develops new fluorescent probes and imaging strategies to study biomolecules in their native environment and map cellular structures with nanometer resolution. The expert has firsthand experience in fluorescence microscopy including confocal, stage scanning, TIRF, wide field, and PALM/STORM microsopy, optics, fluorescent probes photophysics, protein engineering, protein expression and purification, protein and DNA bioconjugation, genetic engineering and molecular biology, cell culture, biochemistry of cell membranes, intracellular targeting and delivery techniques, fluorescence quantification diffusion analysis and image treatment. The expert multidisciplinary research has attracted financial support by the National Institut of Health (NIH), the National Science Foundation (NSF), the Marie-Curie Actions and the European Molecular Biology organization (EMBO).
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biophysics

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fluorescence microscopy

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single-molecule detection

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biotin-avidin technology

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cell membrane transport

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cell membrane biophysics

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green fluorescent protein


Show Secondary and Basic Areas of Expertise
Localities:
Expert may consult nationally and internationally, and is also local to the following cities: Los Angeles, California;  Long Beach, California;  Santa Ana, California;  Anaheim, California;  Riverside, California;  Bakersfield, California;  Glendale, California;  Huntington Beach, California;  San Bernardino, California;  and Oxnard, California.

Education:
Year   Degree   Subject   Institution   Honors
2007   PhD   Biochemistry and Molecular Biology   University of California Los Angeles  
1999   BSc   Biomedical Sciences   Nottingham Trent University   First Class Honors
1996   Diplome Universitaire de Technologie   Genie Biologique, Analyses Biologiques et Biochimiques   Institut Universitaire de Technologie Clermont-Ferrand  

Work History:
Years   Employer   Department   Title   Responsibilities

2011 to

 

(Undisclosed University)

 

Biological Sciences and Chemistry

 

Assistant Professor

 

Principal Investigator of the Single Molecule Biophotonics Groups

2007 to 2011

 

Ecole Normale Superieure

 

Departement de Physique, Groupe Optique et Biologie

 

Marie-Curie and EMBO Post-doctoral Fellow

 

Expert develops fluorescent probes (dyes, fluorescent proteins, quantum dots…) and microscopy techniques for single molecule imaging and tracking in living cells and organisms.

2002 to 2007

 

University of California, Los Angeles

 

Department of Chemistry and Biochemistry

 

Research Assistant

 

Expert develops surface and colloidal chemistry's of semiconductor quantum dots for fluorescence imaging of biological samples. He designs and build optical set up for high sensitivity fluorescent microscopy and engineers proteins and high affinity pairs for single molecule microscopy in living cells. Expert also develops cell models for single molecule imaging and tracking with quantum dots and studies the diffusional dynamics of membrane proteins associated with micro-domains in living cells.

2001 to 2002

 

University of California, Berkeley

 

Biophysics

 

Research Assistant

 

Expert develops surface chemistry of nanomaterials and analytical techniques and processes for colloidal characterization of bio-compatible quantum dots. Expert also characterize quantum dot by single molecule fluorescence microscopy.

1999 to 2001

 

Lawrence Berkeley National Laboratory

 

Material Sciences and Physical Biosciences Division

 

Research assistant

 

Expert synthesizes semiconductor quantum dot probes and characterizes their photo-physical properties. He also develops bio-compatible surface chemistry and bio-labeling strategies.

1997 to 1998

 

Hoffmann-La Roche

 

Pharma Division

 

Research assistant

 

Expert performs R&D on fluorescence techniques and labeling of recombinant proteins (tumor necrosis factor, interferon…) and develops a fluorescence linked immuno binding assays for quality control analysis of biotechnological products. Expert works under Good Manipulating Practices and Good Laboratory Practices (GMP/GLP).


Career Accomplishments:
Associations/Societies

The Biophysical Society

Professional Appointments

Marie-Curie Post-doctoral Fellow; EMBO Post-doctoral Fellow

Awards/Recognition

Marie-Curie Intra-European Research Fellowship Award; EMBO Long-Term Research Fellowship Award; Best PhD Dissertation Award, UCLA Department of Biochemistry; Keystone Symposia Scholarship; EMBO Short-Term Fellowship Award; International Union of Pure and Applied Biophysics Travel Fellowship; Graduate Award for Excellence in Research UCLA Department of Chemistry and Biochemistry


Publications:
Publications and Patents Summary

Expert has 22 publications, 1 recent book on nanotechnology, 2 granted patents and 1 patent application

Selected Publications and Publishers  
 - Proceedings of the National Academy of Sciences  
 - Traffic  
 - Science  
 - Journal of the American Chemical Society  
 - Journal of Physical Chemistry B  

Consulting Services:
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
1999 to 2007   USA   The expert was a research assistant at the Lawrence Berkeley National Laboratory, at the University of California in Berkeley and in Los Angeles.
1997 to 1998   Switzerland   The expert was a research assistant in Hoffman-La Roche in Basel

Language Skills:
Foreign Language   Description
English   Fluent
French   Fluent
German   Intermediate

 

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