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 Expert  726625

Expert in Psychopharmacology, Drug Development, Medical Devices

Available for your Consulting and Expert Witness Needs

Massachusetts (MA)
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise:

Listed with other top experts in: 

Expert's training in psychiatry has focused on biological psychiatry (the biological basis of psychopathology) and on psychopharmacology. He currently directs the Developmental Biopsychiatry Research Program and the Laboratory of Developmental Psychopharmacology at McLean Hospital/Harvard Medical School. He has a broad understanding of the biological basis and psychopharmacological treatment of the major psychiatric disorders. However, his particular expertise is in the biological basis and pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD), major depression, and post-traumatic stress disorder stemming from childhood abuse. He has successfully utilized neuroimaging methods to identify regional brain abnormalities associated with these disorders. He has developed new methods for diagnosing these disorders that have been patented, FDA-cleared, and licensed. His work in this area has been funded by the NIH, pharmaceutical companies, charitable foundations, medical device manufacturers and private donors. He has also received method and use patents for new pharmaceutical agents that have been licensed and undergone clinical trial testing.

biological psychiatry



The diagnosis, neurobiology and treatment of ADHD is a leading area of specialty interest for Expert. He was one of the first individuals to publish functional MRI findings in ADHD, and he has developed an FDA-cleared medical device that aids in the assessment of children, adolescent and adults with ADHD. He is the inventor on several patents related to the diagnosis and treatment of ADHD. His research on ADHD often involves a treatment component with methylphenidate, and he is an expert in the pharmacokinetics and pharmacodynamics of methylphenidate.

attention-deficit hyperactivity disorder





The neurobiology and treatment of depression has been a long-standing interest of Expert. He has conducted studies of depression across the lifespan with funding from the NIMH and NARSAD. Although he is well-versed in the area, he is particularly well-known for his expertise in seasonal affective disorder. One of Expert's major contribution was to publish the first report indicating an association between treatment with SSRIs and emergence of suicidal ideation. He has provided a thoughtful analysis of factors that underlie this association. He also is an inventor on a patent for the use of R(-) fluoxetine in the treatment of depression, recognizing early on that the enantiomers of fluoxetine differed substantially in metabolism, duration of action, and degree of anxiogenic effects.

depression (mood)


seasonal affective disorder


antidepressant drug



Expert was the first investigator to advance the idea that childhood abuse or adversity exerts its deleterious effects by altering trajectories of brain development. He has published extensively on the effects of exposure to multiple forms of adversity such as childhood sexual abuse, witnessing domestic violence, parental verbal abuse, and exposure to harsh corporal punishment. These studies have been supported by federal research grants from the National Institute of Mental Health and National Institute of Drug Abuse. He lectures world-wide on this topic.

child abuse


psychiatric trauma


sexual abuse

Expert has been involved as the lead investigator in several studies assessing the accuracy of medical devices used to aid in the diagnosis of psychiatric disorders. These include both devices he has invented and licensed, and devices created by other individuals or companies. He is quite familiar with FDA procedures for the regulatory clearance of medical devices in the psychiatric area.

diagnostic test evaluation

Expert has had a long-standing interest in dopamine as a neurotransmitter, development of the dopamine system, and drugs that affect dopamine. He has received several grants from the National Institute of Mental Health to conduct preclinical research on dopamine system development, and has published extensively in this area.


Expert has a long-standing interest in dose-response analysis, writing one of the first programs for personal computer that provided a state-of-the art analysis of pharmacodynamic effects. He also wrote one of the first programs for analyzing biphasic dose-response curves. This program was used in a classic paper by Baldessarini, Cohen and Expert that indicated the benefits of low-to-moderate doses of antipsychotic doses, and the anti-therapeutic effects that emerge at high doses. He has consulted to individuals and companies regarding the analysis of dose-response data.

dose response assessment

Show Secondary and Basic Areas of Expertise
Expert may consult nationally and internationally, and is also local to the following cities: Boston, Massachusetts;  Worcester, Massachusetts;  Springfield, Massachusetts;  Lowell, Massachusetts;  Cambridge, Massachusetts;  Brockton, Massachusetts;  New Bedford, Massachusetts;  Hartford, Connecticut;  Manchester, New Hampshire;  and Providence, Rhode Island.

Year   Degree   Subject   Institution   Honors
1981   MD   Medicine   Yale University School of Medicine  
1977   PhD   Psychology   The Johns Hopkins University   Highest distinctions
1973   BS   Psychology   Rensselaer Polytechnic Institute  

Work History:
Years   Employer   Department   Title   Responsibilities

1981 to




Psychiatry/Developmental Biopsychiatry


Director Developmental Biopsychiatry


He is responsible for the operation and scientific integrity of the Developmental Biopsychiatry Research Program and Laboratory of Developmental Psychopharmacology.

Career Accomplishments:
Professional Appointments

Editorial Board : Journal of Child and Adolescent Psychopharmacology; Editorial Board: Current Pediatric Reviews; Editorial Board: BioPsychoSocial Medicine; Scientific Advisory Board: Juvenile Bipolar Research Foundation; Scientific Advisory Board: Optax, Inc. Scientific Advisory Board: BioBehavioral Diagnostic Corporation; Scientific Advisory Board: Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD); Committee Member, Committee Chairman, ADAMHA, Small Business Innovation Research Program - Initial Review Group; Committee Member, Cellular Neurobiology and Basic Pharmacology Subcommittee (BPN-1), NIMH, Initial Review Group; Committee Member, Psychopharmacology and Neurochemistry Subcommittee (PPNC), NIMH, Initial Review Group; Committee Chairman, Special Emphasis Review Committee, RFA - Integrative Neuroscience: Stress and HPA Axis. ZR1, NIH; Committee Chairman, Review Panel, Fogarty International Collaborative Trauma and Injury Research Training Program (ICTIRT); Committee Chairman, Review Panel, NIH/NIDA, Behavioral Pharmacology & Genetics: Translating and Targeting Individual Differences (ZDA1 SXC-E (03))


Travel Award Fellowship, American College of Neuropsychopharmacology; F.I.R.S.T. Award, N.I.M.H; NARSAD, Callaghan Investigator; NARSAD John W. Alden Trust Investigator; Partners in Excellence Award, Partners Health Care

Medical/Professional Internships

Residency, Psychiatry, McLean Hospital, Harvard Medical School; Chief Resident, Psychopharmacology, McLean Hospital, Harvard Medical School

Publications and Patents Summary

He has 13 issued patents and 191 publications.

Selected Publications and Publishers  
 - Journal of Clinical Psychiatry  
 - The Journal of Neuropsychiatry and Clinical Neurosciences  
 - Journal of Child and Adolescent Psychopharmacology  
 - The American Psychiatric Press Textbook of Neuropsychiatry and Behavioral Neurosciences  

Government Experience:
Years   Agency   Role   Description
2009 to 2009   NIH/NIDA   Chairman   He chaired the special Review Panel on Behavioral Pharmacology & Genetics: Translating and Targeting Individual Differences (ZDA1 SXC-E (03))
2006 to 2006   Fogarty International Center   Chairman   He chaired the Review Panel on Trauma and Injury Research Training Programs (ICTIRT)
2002 to 2002   NIH/NICHHD   Discussion Leader   He served as Discussion Leader on an NICHHD Workshop on Children Exposed to Violence: Current Status, Gaps, and Research Priorities
1989 to 1993   NIMH/NIH   Committee Member   He served on the initial review groups Cellular Neurobiology and Basic Pharmacology (BPN-1) and Psychopharmacology and Neurochemistry (PPNC)

Consulting Services:
Selected Consulting Examples:
  • He is currently serving as an expert witness to a law firm working on a patent priority claim, providing expertise on the dosing and pharmacokinetics of the antidepressant agent in question.
  • He has served as a consultant to the following pharmaceutical manufacturers regarding design of research studies. Copley Pharmaceuticals (1997-99) Watson Pharmaceuticals (1997-98); Sepracor (1998-2002); Sention (2004-2006)
  • He is currently serving as a consultant to medical device manufacturers and their representative regarding design of research studies, data analysis and presentation of clinical trial data to the FDA.
  • He has served as a consultant to investment groups seeking to ascertain need and perceived value of new medications, drug delivery systems, and medical devices.
  • He has consulted to law firms regarding product liability cases related to the safety of medications.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Expert Witness Experience Summary:
Expert has served as an expert witness in a moderate number of cases. These include two capital cases with charges of first degree murder, where Expert's testimony was instrumental in reduction of charges to manslaughter. He served as an expert witness in one product liability lawsuit, which after his deposition was successfully settled out of court. He also provided advice to several law firms pursuing similar claims. He has provided testimony on deposition for malpractice cases that were successfully settled. He is currently providing expert witness testimony on a patent suit involving a popular antidepressant drug. He is open to providing expert testimony in commercial suits regarding psychiatric medications and medical devices. He is not currently open to providing testimony on matters of medical malpractice.
Recent Litigation Client Requests:
  • Organic chemistry expert for consulting on Methamphetamine issues.
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
2001 to 2005   Japan/ Tokyo & Kobe   He provided consultation and guest lectures on an annual basis regarding educational physiology and psychosomatic medicine. He provided two years of advance research training in the US for a Japanese pediatric neurologist supported by her hospital and medical school.
2006 to 2006   Czech Republic/Prague   He provided the Keynote Address, celebrating the founding of the Center for the Neuropsychiatric Study of Trauma, 1st Medical Faculty, Charles University, Prague, Czech Republic
2004 to 2004   Rome, Italy, Valencia, Spain, Lisbon, Portugal   He provided Keynote addresses at the Human Brain Conference II in Rome, the VIII International Conference at the Queen Sophia Center in Valencia, and the 1st ECSA Conference on Hyperactivity and Attention Disorders in Lisbon.
2008 to 2008   UK/London   He was the Keynote Speaker at the Annual Child Mental Health Conference, Centre for Child Mental Health
2008 to 2008   Netherlands/Amsterdam   He was a Keynote Speaker at the First Annual Conference, European Society for Trauma and Dissociation

Market Research:
Expert is a key opinion leader in the areas of ADHD, depression and traumatic stress. He has consulted to pharmaceutical manufacturers, device manufacturers, governmental agencies, hospitals and individual practitioners. He is well-aware of current trends, the limitations of existing technologies, and need for new and improved alternatives.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:

Expert has developed, organized and delivered hundreds of seminars including on Mechanism of Action and Use of Neuroleptic Drugs, Psychopharmacology of Borderline Personality Disorder, Childhood Depression, on Attention-Deficit/Hyperactivity Disorder, Psychopharmacology of Posttraumatic Stress Disorder, Monoamine and much more.

Other Skills and Services

Indepth understanding of statistical procedures.


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