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 Expert  728760

Expert in Bone Biology, Advanced Microscopy, 3D Imaging Analysis


Available for your Consulting and Expert Witness Needs

United Kingdom
Education Work HistoryPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise:

Listed with other top experts in: 

Expert has developed expertise in bone biology including effects of growth factors, growth factor receptor signalling and expression, endocrinology (TSH, T3 and thyrostimulin) and orthopaedics.

Expert recently developed novel advanced 3D microscopy protocols to acquire images of large volumes of tissue (tiledZ stacks) which may be applied to any bone cancer preclinical model with fluorescent tags (for example myeloma, breast and prostate cancers). This permits quantitative analysis of cubic millimeters of tissue whilst maintaining single cell sensitivity. Expert is applying this method to locate early colonising cancer cells in the bone microenvironment and characterise the pre-metastatic and post-metastatic niche. To complement this Expert also developed a very high resolution microCT protocol to enable previously unknown tiny skeletal structures in murine skulls to be analysed. This has been successfully applied to assess the effects of bisphosphonates and other bone modulating therapeutics in a preclinical model and represent a putative pre-metastatic niche.

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bone cancer

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cancer research

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metastasis

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oncogenesis


Show Secondary and Basic Areas of Expertise

Education:
Year   Degree   Subject   Institution  
2007   PhD   Bone Biology   Imperial College London, UK  
1998   MSc   Medical Biotechnology   Newcastle University, UK  
1996   BSc   Biochemistry   Newcastle University, UK  

Work History:
Years   Employer   Title   Responsibilities

2007 to 2010

 

University of Sheffield, UK

 

Research Associate

 

Supervision of MSc and PhD students. Project grant member - characterising a cancer niche.

2002 to 2007

 

Imperial College London, UK

 

Research Associate

 

Teaching all new staff, PhD project, Laboratory protocol developments

1998 to 2002

 

Newcastle University, UK

 

Junior Research Associate

 

Laboratory duties. Developing an anti-OPG antibody.


Publications:
Publications and Patents Summary

He has numerous peer reviewed publications, being a key player in successful grant applications and is presently in discussions to establish a programme for a start up stem cell company in Asia.


Consulting Services:
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Market Research:
With new techonology applications in imaging the future of cancer research is charactersing the early events permitting growth.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:
Training/Seminars

Microscopy training - advanced, multiphoton, fluorescence, second harmonics. 3D analysis, proximity analysis. In vivo protocols teaching.

Other Skills and Services

He has developed a wide experience in bone biology and have specialised in orthopaedics, endocrinology and bone cancer.


 

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