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 Expert  728818

Expert in Neurobiology, Neurodegenerative and Vascular Disorders, Estrogen-mediated Vascular Modulation


Available for your Consulting and Expert Witness Needs

United Kingdom
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

Listed with other top experts in: 

The Expert has conducted intensive research in vascular biology including modulation of vascular tone by regulation of calcium homeostasis. Calcium (Ca2+) enters the cytoplasm of vascular smooth muscle and endothelial cells via various pathways (calcium channels, intracellular calcium stores) and dysfunction of these pathways contribute often to vascular diseases such as hypertension.

One of his research projects was to determine how Ca2+ dysregulation can contribute to the pathophysiology of pre-eclampsia, a serious complication during the mid/third trimester of pregnancies. By using calcium imaging and electrophysiological techniques he characterized Ca2+ signalling in vascular endothelial and smooth muscle cells.

As Ca2+ is one of the key regulators of nitric oxide (NO) synthase NOS he additionally analyzed NOS signalling in tissue obtained from pregnant women affected by pre-eclampsia.

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cardiovascular physiology

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cardiovascular research

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cardiovascular system

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potassium channel blocker

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vascular biology

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vascular disease

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nitric oxide

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nitric oxide donor

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nitrous oxide

The Expert is currently investigating the mechanisms underlying various neurodegenerative diseases such as Alzheimer's (AD), Parkinson (PD), Huntington disease (HD) or Prion disease all of which exhibit a progressing neuronal cell death. Here he is interested in modulation of ion channels (potassium, sodium, calcium) contributing to neuronal dysfunction. NO production from inflammation and resulting oxidative stress is also a significant factor in AD, PD, multiple sclerosis (MS) and HD and currently studies using cell culture and Drosophila models of HD being conducted.
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neuroscience

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nerve

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nervous system

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nervous system disease

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Alzheimer's disease

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central nervous system disease

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dementia

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neurobiology

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Parkinson disease

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prion disease

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neurodegenerative disease

The Expert has conducted intensive research in vascular biology including modulation of vascular tone by regulation of calcium homeostasis. Calcium (Ca2+) enters the cytoplasm of vascular smooth muscle and endothelial cells via various pathways (calcium channels, intracellular calcium stores) and dysfunction of these pathways contribute often to vascular diseases such as hypertension.
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intracellular calcium

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calcium channel

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calcium homeostasis

The Expert is investigating physiological effect of NO on auditory functions. Here he has characterized the involvement of NO in auditory processing as mediated in the auditory brainstem. He is applied a fluorescent method to detect NO levels upon neuronal activity by using a rhodamine-based chromophore diaminorhodamine-4M (DAR-4M). Several different nuclei are involved in sound source localization (medial superior olive (MSO), lateral superior olive (LSO), the superior-paraolivary nucleus (SPN) and nuclei of the lateral lemniscus (NLL)) and signal transmission encoded by action potential firing is depending on the action of various ion channels (e.g. potassium, sodium). His expertise in physiological regulation of these mechanisms has also been extended to investigate pathological alterations occurring during neurodegenerative diseases (e.g. tinnitus). Different potassium channels have been implicated in degenerative/apoptotic signalling and by using electrophysiological methods (patch clamp technique) the involvement of these ion channels can be characterized.
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auditory disease

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auditory neurophysiology

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auditory physiology

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neurophysiology

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physiology

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tinnitus

A general involvement of nitric oxide (NO) has been documented in many neurodegenerative disorders and his primary aim is to investigate how this free radical gas is involved in oxidative stress-mediated neuronal cell death. The amount of cellular oxidative stress is determined by a balance of physiological antioxidant systems (Superoxide Dismutase, Catalase, Glutathione Peroxidase) and the generation of reactive oxygen species (e.g. Superoxide generated by Mitochondria, Xanthine Oxidase, NAD(P)H Oxidase, NOS). Thus, if this balance is shifted towards enhanced generation of reactive oxygen species (ROS) with lacking antioxidant defense, cells experience detrimental effects such as lipid peroxidation or DNA damage.
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oxygen radical biochemistry


Show Secondary and Basic Areas of Expertise

Education:
Year   Degree   Subject   Institution  
2001   PhD   Vascular Physiology   King's College London, UK  
1996   MSc   Biophysics   Humboldt University Berlin, Germany  

Work History:
Years   Employer   Title   Responsibilities

2006 to 2013

 

(Undisclosed)

 

Senior Invstigator Scientist

 

Leading research projects, Conducting research experiments, Supervision of staff.

2004 to 2006

 

University Heidelberg, Germany

 

Postdoctoral Scientist

 

Conducting research experiments

2002 to 2004

 

Max Planck Institute Tuebingen, Germany

 

Postdoctoral Scientist

 

Conducting research experiments

2001 to 2002

 

King's College London, UK

 

Postdoctoral Scientist

 

Conducting research experiments

2013 to

 

(Undisclosed)

 

Group Leader

 

Leading competitive research in the area of degenerative diseases, including signaling involved in Nitric Oxide toxicity. His team consists of post-doctoral and student staff.


Career Accomplishments:
Associations/Societies

He is a member of the Physiological Society, UK, and Society for Neuroscience, USA.

Professional Appointments

2013-date: Group Leader at the Medical Research Council Toxicology Unit

Awards/Recognition

He received the MRC ARS award in 2009.


Publications:
Publications and Patents Summary

He has 40 publications in high profile peer-reviewed journals, including 3 publications in Neuron and 2 in Nature.

Selected Publications and Publishers  
 - Journal of Physiology  
 - Advances in Clinical Neuroscience and Rehabilitation  
 - Antioxidants and Redox Signaling  
 - Neuron  

Consulting Services:
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Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

International Experience:
Years   Country / Region   Summary
1996 to 2002   UK   He studied during his PhD and postdoctoral employment vascular disorders investigating abnormalities in calcium regulation and nitric oxide signalling.
2006 to 2010   UK   He studied the underlying mechanisms of neurodegenerative disorders, such as AD or PD and the involvement of ion channel dysfunction related the neuronal cell death. In particular, oxidative stress and nitric oxide involvement are key areas of interest.

Language Skills:
Foreign Language   Description
English   High proficiency as he lived over 16 years in the UK.
German   Mother tongue.
Russian   8 years of school language.

Additional Skills and Services:
Training/Seminars

2014 Research Lecturer on ‘NO modulation of synaptic release parameters', University of Edinburgh, Edinburgh, UK 2014 Research Lecturer on ‘NO mediated synaptic dysfunction', Imperial College, London, UK 2014 Research Lecturer on ‘Studying early synaptic dysfunction mediated by NO', Neuroscience Day, University of Leicester, Leicester, UK 2013 Research Lecturer on ‘Studying prion protein function/dysfunction at the synapse' University of Aberdeen, Aberdeen, UK 2012 Research Lecturer on ‘Nitric oxide - an activity-dependent regulator of neuronal intrinsic excitability' University of Sussex, Brighton, UK 2012 Research Lecturer on ‘The Physiology of auditory processing' University of Leicester, Leicester, UK 2012 Symposium Seminar ‘Nitric oxide dependent modulation of neuronal excitability', Physiological Society, Edinburgh, UK 2009 Research Lecture on Redox Modulation of Calcium Signaling at the Symposium “Redox Biology in Health and Disease”, University of Nottingham, UK (Feb 2009) - 2008 Seminar on Modulation of Postsynaptic Excitability by Nitric Oxide at the MRC Toxicology Unit, University of Leicester, UK (2008) -

Teaching Seminar on The Etiology of Pre-eclampsia at the University of Surrey Guildford, School of Nursing and Midwifery, UK (May 1999) -

Teaching Seminar on The Etiology of Pre-eclampsia at the University of Surrey Guildford, School of Nursing and Midwifery, UK (May 1998) -

Undergraduate Teaching:

2001-2002 Vascular physiology undergraduate practical workshops Supervision of intercalated students, King's College London

2004-2006 Synaptic Plasticity, Learning and Memory, practical workshop, seminars Supervision of Diploma Students, University Heidelberg

2009-present Neuroscience Tutorials for 3rd year students, University Leicester -

Postgraduate Teaching: PhD student supervision


 

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