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 Expert  729028

Expert in Biomedical Sciences, Vascular Biology, Angiogenesis


Available for your Consulting and Expert Witness Needs

United Kingdom
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness Market Research

Summary of Expertise:

Listed with other top experts in: 

Expert completed his PhD at St George's Hospital Medical School, on the microvascular parameters affecting post mastectomy lymphoedema in patients. After a year learning molecular biology at Glasgow University in Drosophila genetics, he spent three years as a postdoctoral researcher at the University of California at Davis, where he developed the existing single capillary cannulation technique to examine chronic regulation of permeability by growth factors, and started investigating VEGF signalling. He continued these studies as a lecturer at the University of Leicester, investigating the mechanism by which VEGF increases permeability using novel tyrosine kinase inhibitors. During that time he developed angiogenesis protocols to investigate VEGF signalling during blood vessel growth and moved to the University of Bristol as a BHF research fellow. He was awarded a BHF lectureship, and in collaboration with Dr Steven Harper, a consultant nephrologist at Southmead Hospital, established the Microvascular Research Laboratories within the School of Veterinary Sciences.

In that year he discovered the anti-angiogenic class of VEGF splice variants, and now investigates the potential of VEGF-splice variants, VEGF-induced angiogenesis and arteriogenesis, VEGF-receptor tyrosine kinase inhibitors, VEGF-activated ion channels and VEGF induced lymphatic metastasis. He discovered, with Jacqui Shields that melanomas can metastasise through recognising chemokines secreted from lymphatics (metastatic chemotaxis), and that this occurs through CCL21/CCR7 interactions. With Dr Neal, he discovered the sub-podocyte space of the kidney glomerulus, the first new urinary space in the kidney for 150 years. He was appointed Professor of Microvascular Biology and Medicine in the Department of Physiology and Pharmacology in Bristol.

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angiogenesis

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angiogenesis inhibitor

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blood capillary

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blood vessel

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endothelial cell

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endothelial cell biology

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endothelium

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malignant melanoma

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myocardial revascularization

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revascularization

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skin tumor

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vascular biology

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vascular endothelial cell growth factor

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diabetic retinopathy

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macular degeneration

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capillary permeability


Show Secondary and Basic Areas of Expertise

Education:
Year   Degree   Subject   Institution  
1992   PhD   Physiology   University of London  
1989   BSc   Zoology   University of Newcastle upon Tyne  

Work History:
Years   Employer   Department   Title   Responsibilities

2007 to

 

(Undisclosed)

 

School of Physiology and Pharmacology

 

Professor of Microvascular Biology and Medicine

 

He is responsible for the academic, scientific, translational and educational progress of the Microvascular Research Laboratories within the School of Physiology and Pharmacology


Career Accomplishments:
Associations/Societies

British Microcirculation Society, The Microcirculatory Society, The European Microcirculation Society, The Physiological Society, The American Physiological Society.

Awards/Recognition

Dr Hans and Mrs Gertrude Hirsch Award, Fight for Sight. British Heart Foundation Lectureship in Basic Biomedical Sciences (2006). Renewal of this highly competitive award to "non clinical researchers who have shown outstanding ability in carrying out original and independent research". Skin Cancer Research Fund 25th Anniversary Clinical Training Laboratory Award. The SCaRF awarded me £100,000 to help support research training for plastic surgeons in skin cancer. This was an ad hoc award to celebrate their 25th anniversary and was the only one of its kind made. Van Leeuwenhoek Outstanding Young Investigator Travel Award. European Society for Microcirculation. Christian Crone Outstanding Young Investigator Award, Microcirculatory Society.


Publications:
Publications and Patents Summary

104 published papers in peer reviewed journals, 1 patent awarded, 7 patent applications, four patents licensed.

Selected Publications and Publishers  
 - Cancer Research  

Consulting Services:
Selected Consulting Examples:
  • Advising major pharmaceutical company on research, marketing and clincial applications of VEGF receptor tyrosine kinase inhibitor in cancer.
  • Advising major pharmaceutical company on research, marketing and clinical applications of VEGF inhibitor in eye disease.
  • Member of steering committee as the scientific expert for major drug company for clinical development of lead compound.
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Market Research:
Invited Scientific Adviser to Global Experts Advisory Meeting for Pharmaceutical Industry partner. (Chicago, USA); Invited Scientific Adviser to Global Advisory Board for pharmaceutical company (New Orleans); Invited Scientific Adviser to pan-European Advisory Board of Retinal Specialists (Lisbon); Invited Scientific Adviser to UK pharmaceutical company Advisory Board.

Click the green button above to contact Expert for a free initial screening call regarding your marketing research, industry research, and company research needs.  For research needs involving multiple experts or secondary research, a Research Director can be assigned to coordinate the work into a custom report for you as a potentially quicker and more cost effective alternative to doing this work yourself or hiring a boutique consultancy.  Remember, your initial screening call to speak with Expert is free.

Additional Skills and Services:
Training/Seminars

Gordon Conference on Molecular Mechanisms of Lymphatic Disease International Advisory Committee; International Podocyte meeting. Organising committee; Experimental Biology, Anaheim. Featured topic organiser “Physiological Role of Vascular Endothelial Growth Factors as Homeostatic Regulators;” European Microcirculation Congress, Budapest, International Advisory Board; Gordon Conference on Molecular Mechanisms of Lymphatic Disease International Advisory Committee; World Congress on Microcirculation. Programme committee; European Vascular Biology Meeting. Organising committee; Experimental Biology, San Francisco. Regulation of glomerular filtration by the podocyte. Chair and Organiser; European Society for Microcirculation. Program committee; European Society for Microcirculation. Symposium organiser; Local Organising Committee, European Microcirculation Society meeting, Exeter,


 

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