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 Expert  729269

Expert in Computational Biology: Antibody Modeling, Antibody-Antigen Interaction, Protein Structure Prediction


Available for your Consulting and Expert Witness Needs

Massachusetts (MA)
USA
Education Work History Career AccomplishmentsPublicationsConsulting Services Expert Witness

Summary of Expertise:

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Expert has developed a state of the art antibody variable region (Fv) modeling tool: RosettaAntibody. He also maintains a server. He has also developed a strategy for predicting structures of antibody-antigen interaction complexes. He has extesive expertise in the Rosetta biomolecular structure prediction suite. Additionally he has taken part in the CAPRI challenge for prediction of protein-protein interaction complexes, and some of his predictions has been the most accurate amongst the ones submitted.
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antibody

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antibody production

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protein structure prediction


Show Secondary and Basic Areas of Expertise
Localities:
Expert may consult nationally and internationally, and is also local to the following cities: Boston, Massachusetts;  Worcester, Massachusetts;  Springfield, Massachusetts;  Lowell, Massachusetts;  Cambridge, Massachusetts;  Brockton, Massachusetts;  New Bedford, Massachusetts;  Hartford, Connecticut;  Manchester, New Hampshire;  and Providence, Rhode Island.

Education:
Year   Degree   Subject   Institution   Honors
2010   PhD   Chemical & Biomolecular Engineering   Johns Hopkins University  
2004   M. Tech   Biotechnology and Biochemical Engineering   Indian Institute of Technology (IIT) Kharagpur  
2004   B. Tech   Biotechnology and Biochemical Engineering   Indian Institute of Technology (IIT) Kharagpur   Honors

Work History:
Years   Employer   Department   Title   Responsibilities

2010 to

 

(Undisclosed)

 

Protein Engineering & Antibody Technology

 

Post Doc: Computational Scientist: Antibody Design

 

Develop novel strategies for increasing antibody efficacy.

2004 to 2010

 

Johns Hopkins University

 

Chemical & Biomolecular Engg

 

Graduate Research Assistant

 

Developed antibody homology modeling algorithms: RosettaAntibody (http://antibody.graylab.jhu.edu), protocol for backbone flexible antibody-antigen interaction complex prediction: SnugDock

2003 to 2003

 

University of Cambridge

 

Biochemistry

 

Summer Intern

 

Project: Structural assignment for the Drosophila genome and mapping of known mutations The work comprised of bioinformatics involving high throughput modeling and automatic analysis of results to generate useful statistics. The programming was mainly carried out in Perl and Python, with MySQL being used to store the data.


2002 to 2002

 

National Center for Biological Sciences (NCBS)

 


 

Summer Intern

 

Project: Delving Deep into Deep Orange and Carnation from a Computational Viewpoint The work involved modeling (using MODELLER) of the two Drosophila proteins Deep Orange and Carnation and finally docking them to find out the interacting regions (using GRAMM).


2001 to 2001

 

Tata Institute of Fundamental Research (TIFR)

 

Biological Sciences

 

Visiting Summer Research Program Student

 

Projects: 1) An attempt to find genes responsible for synaptic transmission using Drosophila melanogaster as a model system. The work involved extensive Fly Pushing and screening flies for phototactic and paralytic defects. 2) Effect of Conus toxins on Drosophila melanogaster



Career Accomplishments:
Associations/Societies

Sigma Xi, ACS, AIChE, Biophysical Society

Awards/Recognition

Rob Roy Fellowship


Publications:
Publications and Patents Summary

He has been invited to write a book chapter on antiody modeling to be published in May, 2011. Additionally he has seven international peer-reviewed publications on computational structural bioinformatics with a focus on prediction of structures of antibody and antibody-antigen complexes.

Selected Publications and Publishers  
 - The Journal of Immunology  
 - The Journal of Biological Chemistry  
 - Proteins: Structure, Function, and Bioinformatics  
 - PLoS Computational Biology  
 - Nucleic Acids Research  

Consulting Services:
Click the green button above to contact Expert for a free initial screening call regarding your expert consulting needs.  Expert is available for consulting to corporate, legal and government clients.  Remember, your initial screening call to speak with Expert is free.

Expert Witness:
Click the green button above to contact Expert for a free initial screening call regarding expert testimony, litigation consulting and support, forensic services, or any related expert witness services.  A few litigation needs include product liability, personal injury, economic loss, intellectual property (patent, trademark, trade secret, copyright), and insurance matters.  Remember, your initial screening call to speak with Expert is free.

Language Skills:
Foreign Language   Description
Hindi  
Bengali   Native Speaker
English  

 

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